Clove Flower Extract (Syzygium aromaticum) Has Anticancer Potential Effect Analyzed by Molecular Docking and Brine Shrimp Lethality Test (BSLT)

Herupradoto, Eduardus Bimo Aksono; Latifah, Aprilia Cahya; Suwanti, Lucia Tri; Haq, Kautsar Ul; Pertiwi, Herinda

doi:10.1155/2022/5113742

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The bioactive components in fruits with strong antioxidant and anticancer activities are often polyphenols and their secondary metabolites like flavonoids and proanthocyanidins [ 93 ]. Some members of the Syzygium genus contain phytochemicals such as sesquiterpenes, monoterpenes, hydrocarbons, phenolic compounds, eugenol, and caryophyllene [ 63 ]. Eugenol inhibits the growth of colon, stomach, breast, prostate, melanoma, and leukemia cancers, whereas caryophyllene inhibits the growth of pancreatic, cutaneous, lymphatic, and cervical cancer [ 98 ].…”

Section: Resultsmentioning

confidence: 99%

“…Eugenol inhibits the growth of colon, stomach, breast, prostate, melanoma, and leukemia cancers, whereas caryophyllene inhibits the growth of pancreatic, cutaneous, lymphatic, and cervical cancer [ 98 ]. Also, it is suggested that eugenol’s anticancer effect was achieved by a combination of mechanisms, including induction of apoptosis, cell cycle arrest, and reduction of proliferation, migration, angiogenesis, and metastasis in a variety of cancer cell lines [ 63 ]. Concentration-dependently, arjunolic acid decreased the wound closure rate of PANC-1 cancer cells and triggered a cell-cycle arrest at G0/G1 [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

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Anticancer of genus Syzygium: a systematic review

Abdulrahman

Hama

2023

Exploration of Targeted Anti-Tumor Therapy

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Aim: One in eight fatalities globally are considered cancer-related. The need for cancer therapy is growing. Natural products continue to play a role in drug development, as up to 50% of authorized drugs in the last 30 years have been isolated from natural sources. Methods: Anticancer, antioxidant, antibacterial, antifungal, antiviral, analgesic, anti-inflammatory, and other actions have all been reported in research papers using plants from the Syzygium genus in the treatment and prevention of disease. Results: Results from the anticancer test showed that the genus, especially Syzygium aqueum, Syzygium samarangense, and Syzygium cumini had significant promise as an anticancer agent in vitro against several cancer cell lines. Numerous factors, including phytochemical composition, increased apoptotic activity, decreased cell proliferation, stopped angiogenesis, and reduced inflammation. Conclusions: These results, despite preliminary, show promise for further purification and investigation of bioactive compounds and extracts within the genus Syzygium for their anticancer properties.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Anticancer of genus Syzygium: a systematic review

Abdulrahman

Hama

2023

Exploration of Targeted Anti-Tumor Therapy

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“…Radikal bebas adalah molekul yang dapat merusak DNA selular dan menyebabkan perkembangan kanker. Antioksidan membantu melindungi sel-sel dari stres oksidatif, mengurangi risiko mutasi dan inisiasi pertumbuhan kanker [22]. Selain itu, ekstrak bunga cengkeh juga memiliki efek antiinflamasi yang dapat mengurangi risiko peradangan kronis.…”

Section: Potensi Pengembangan Ekstrak Bunga Cengkeh Sebagai Agen Anti...unclassified

Studi Literatur Potensi Ekstrak Bunga Cengkeh (Syzygium aromaticum) sebagai agen Antikanker

Ni Kadek Diah Ayu Septiandary,

Ni Kadek Warditiani

2023

WSNF

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Berdasarkan data WHO, sebanyak 10 juta orang di dunia meninggal tiap tahunnya akibat kanker. Di Indonesia, penyakit kanker telah menduduki peringkat ke-8 di Asia Tenggara dengan angka kejadian mencapai 136 orang per 100.000 penduduk. Sampai saat ini, pengobatan untuk penyakit kanker masih terus dikembangkan. Akan tetapi, pengobatan umum untuk terapi kanker menimbulkan berbagai efek samping dan terdapat peningkatan resistensi terhadap obat antikanker yang dapat memperburuk perkembangan obat antikanker di masa depan. Oleh karena itu, perlu dilakukan pencarian alternatif melalui produk alami, seperti rempah maupun tanaman obat yang berpotensi sebagai antikanker. Salah satu tanaman yang berpotensi sebagai antikanker adalah bunga cengkeh (Syzygium aromaticum). Tujuan penelitian ini adalah untuk mengetahui potensi senyawa metabolit sekunder dalam bunga cengkeh yang dapat digunakan sebagai agen antikanker dan mekanisme kerjanya sebagai antikanker. Penelusuran literatur dilakukan menggunakan search engine seperti Pubmed, Springer, ScienceDirect, dan Google Scholar. Kemudian dilakukan analisis dan pengkajian terhahdap artikel yang diperoleh. Hasil analisis disajikan dalam bentuk review studi literatur ilmiah. Dari pengkajian diperoleh hasil bahwa bunga cengkeh memiliki potensi sebagai antikanker karena memiliki kandungan minyak atsiri eugenol dan metabolit sekunder seperti flavonoid yang memiliki efek sitotoksik pada sel kanker. Ekstrak methanol cengkeh telah terbukti dapat menginduksi apoptosis seluler dari sel karsinoma (MCF-7) dan sel hepatokarsinoma (HePG-2). Selain itu, penelitian mengenai tingkat apoptosis dengan metode flow-cytometry pada sel kanker servik HeLa menunjukkan bahwa minyak cengkeh memiliki efek pro-apoptosis pada sel kanker serviks secara in vitro.

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“…Artemia salina is often used in preliminary toxicity assays due to its sensitivity to various chemical substances [28], including compounds present in essential oils [29]. While the A. salina lethality test is commonly used for preliminary toxicity screening, it is important to note that the results obtained from this test may not directly translate to the potential toxicity of essential oils in humans or other animals [30][31][32]; however, they can bring a potential toxicity perspective to natural products. Furthermore, the toxicity in A. salina may be related to the inhibition of acetylcholinesterase (AChE) [33], which is an enzyme that plays a crucial role in the termination of nerve impulse transmission by catalyzing the hydrolysis of the acetylcholine neurotransmitter; several studies reported AChE as a potential molecular target to cause the death of A. salina using molecular modeling, which can be a useful tool to analyze the potential interactions between the molecules present in essential oils and AChE [34].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Preliminary Toxicity, and Antioxidant Potential of Piper marginatum Sensu Lato Essential Oils and Molecular Modeling Study

et al. 2023

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The essential oils (OEs) of the leaves, stems, and spikes of P. marginatum were obtained by hydrodistillation, steam distillation, and simultaneous extraction. The chemical constituents were identified and quantified by GC/MS and GC-FID. The preliminary biological activity was determined by assessing the toxicity of the samples to Artemia salina Leach larvae and calculating the mortality rate and lethal concentration (LC50). The antioxidant activity of the EOs was determined by the DPPH radical scavenging method. Molecular modeling was performed using molecular docking and molecular dynamics, with acetylcholinesterase being the molecular target. The OES yields ranged from 1.49% to 1.83%. The EOs and aromatic constituents of P. marginatum are characterized by the high contents of (E)-isoosmorhizole (19.4–32.9%), 2-methoxy-4,5-methylenedioxypropiophenone (9.0–19.9%), isoosmorhizole (1.6–24.5%), and 2-methoxy-4,5-methylenedioxypropiophenone isomer (1.6–14.3%). The antioxidant potential was significant in the OE of the leaves and stems of P. marginatum extracted by SD in November (84.9 ± 4.0 mg TE·mL−1) and the OEs of the leaves extracted by HD in March (126.8 ± 12.3 mg TE·mL−1). Regarding the preliminary toxicity, the OEs of Pm-SD-L-St-Nov and Pm-HD-L-St-Nov had mortality higher than 80% in concentrations of 25 µg·mL−1. This in silico study on essential oils elucidated the potential mechanism of interaction of the main compounds, which may serve as a basis for advances in this line of research.

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Clove Flower Extract (Syzygium aromaticum) Has Anticancer Potential Effect Analyzed by Molecular Docking and Brine Shrimp Lethality Test (BSLT)

Cited by 5 publications

References 20 publications

Anticancer of genus Syzygium: a systematic review

Anticancer of genus Syzygium: a systematic review

Studi Literatur Potensi Ekstrak Bunga Cengkeh (Syzygium aromaticum) sebagai agen Antikanker

Chemical Composition, Preliminary Toxicity, and Antioxidant Potential of Piper marginatum Sensu Lato Essential Oils and Molecular Modeling Study

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