This study assessed the effects of high-fibre olive pomace (OP) and exogenous multi-enzyme (phytase, cellulase, and xylanase) on broiler chickens' growth performance, internal organs, intestinal morphology, blood traits, lipid profile of serum, and health. 300 one-day-old Ross 308 chicks were randomly divided into six groups using a 2 × 3 factorial design with 0 and 0.5g/kg multi-enzyme and 0, 5, and 10% olive pomace. The diet was primarily based on corn and soybean meal. The experiment was carried out in three stages: starter, grower, and finisher. The results indicated that the inclusion of OP at both 5% and 10% levels did not negatively impact broilers' performance (P > 0.05). However, supplementing the diet with multi-enzyme significantly increased feed consumption, body weight, and weight gain (P < 0.05). Furthermore, chickens offered with 10% OP + multi-enzyme exhibited the best performance compared to other experimental groups. The mortality rate also showed a non-significant decline of almost 5% (P > 0.05). Additionally, administration of OP and multi-enzyme or a combination of them to the broilers' diet improved serum lipid profile and liver enzyme activity (P < 0.05) and did not affect the relative weight and length of internal organs, and intestinal histomorphology (P > 0.05). In conclusion, simultaneous use of multi-enzyme and diet containing olive pomace could improve the serum lipid profile, liver enzyme activity, and overall health without adverse effect on broilers performance.