Clozapine augmentation with amisulpride

Porcelli, Stefano; Serretti, Alessandro; Bianchini, O.

doi:10.1503/jpn.140094

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2015

2023

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Cited by 6 publications

(1 citation statement)

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“…The efficacy of clozapine augmentation with amisulpride has been demonstrated in a single-blind, randomized study [ 5 ]. The efficacy of amisulpride may be related to its unique ability to blockade D 2 /D 3 receptors, especially in limbic regions, rather than striatal structures [ 6 ]. Moreover, the D 2 partial agonism of amisulpride helps to explain both its antipsychotic property and fewer incidences of extrapyramidal symptoms [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Amisulpride Augmentation for Clozapine-Refractory Positive Symptoms: Additional Benefit in Reducing Hypersialorrhea

Bogorni

Moreira

Pimentel

et al. 2015

Case Reports in Psychiatry

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One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment. Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients. This is a case of a 30-year-old male with refractory schizophrenia; in this patient, the remission of residual positive symptoms, as well as the reduction of CIH, was achieved by treatment with clozapine augmented with amisulpride.

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Section: Discussionmentioning

confidence: 99%