Clozapine for the treatment of neurogenic bladder

Kumar, Amardeep; Rk, Chadda; Kumar, Nand; Balan, Sabish; Srinivasan, Shiva Prakash

doi:10.1002/nau.20399

Cited by 6 publications

(25 citation statements)

References 10 publications

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“…Four papers did not mention the treatment status of schizophrenia or current/past antipsychotic use 7,9,32,43 . Eighteen papers described previous antipsychotic trials 6,14,17–19,26,30,34–38,40–42,44,48,49 . Of these 18 papers, eight stated the doses of the previous antipsychotics 14,30,34,36,38,40,41,48 and one paper mentioned the duration of the previous antipsychotic trials 41 …”

Section: Resultsmentioning

confidence: 99%

“…Thirteen papers detailed the current antipsychotics the patient was prescribed, 6,8,14–19,26–31,33–42,44–49 and of these, 26 papers stated the current antipsychotic doses 8,14,15,17,18,26–31,33–42,44–46,48,49 …”

Section: Resultsmentioning

confidence: 99%

“…In terms of LUTS‐specific terminology, 14 papers mentioned only urinary incontinence, 8,9,14,16,18,28–30,32,34–37,42 while 13 papers mentioned only (nocturnal) enuresis/bedwetting/nocturnal incontinence 15,17,19,38,39,41,43–49 . Seven papers included other LUTS in addition to the above, 6,7,26,27,31,33,40 but only one of these papers used the phrase “lower urinary tract symptoms.” 27 Of the 20 papers that mentioned urinary incontinence, 6–9,14–16,18,26–32,34–37,42 six subcategorized it 6,7,26,27,30,31 . Of these six papers, two did not detail how they subcategorized urinary incontinence, 7,30 three used urodynamics 6,26,31 and one used direct questioning 27 …”

Section: Resultsmentioning

confidence: 99%

“…Three papers included an evaluation of the patient by a urologist 36,40,42 . Seven papers performed urodynamics 6,14,26,31,33,35,42 . Three of these papers described the urodynamic tests performed in detail 6,31,33 .…”

Section: Resultsmentioning

confidence: 99%

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The association of lower urinary tract symptoms with schizophrenia and its treatments: A narrative review

Schofield,

Taylor,

Drake

2023

Neurourology and Urodynamics

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BackgroundA higher incidence of lower urinary tract symptoms (LUTS) in people with schizophrenia compared to the general population is often suggested. However, it is not clear whether this is a genuine association, and whether it is a direct result of schizophrenia itself, or a side‐effect of certain antipsychotics.MethodsWe undertook a narrative review evaluating how the published literature reports the relationship between LUTS and schizophrenia and its treatments. We searched Embase, Ovid Emcare, and Ovid MEDLINE(R) ALL to August 2022, limited to the English language. We selected the following search terms: schizophrenia, schizophrenic, LUTS, overactive bladder, urinary urgency, urinary incontinence, overactive bladder, enuresis, nocturnal enuresis, and voiding dysregulation. We identified seven domains for assessment in advance of commencing the review. These were the categorization, description, and treatment status of schizophrenia; evaluation of LUTS; categorization of LUTS confounders; recapturing of the disease states of both schizophrenia and LUTS after therapies; assessment of the association between LUTS and schizophrenia and/or antipsychotics.ResultsThe association between LUTS and schizophrenia was poorly described. The evidence was low quality and focused predominantly on urinary incontinence as an antipsychotic side effect, neglecting other LUTS. The status of schizophrenia was often incompletely characterized, and no papers made use of a bladder diary or LUTS‐specific questionnaires to assess symptoms. No papers collected information about LUTS in patients not on antipsychotics, nor did any thoroughly evaluate the influence of confounding variables. Despite the tendency of symptoms and severity of both conditions to fluctuate over time, no studies fully assessed the status of both schizophrenia and LUTS at baseline, therapy initiation, and follow‐up.ConclusionsIt is not possible to state whether there is an association between LUTS and schizophrenia or its treatments. This review highlights the need to improve research and clinical management of the urinary tract in schizophrenia, with meticulously designed longitudinal studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The association of lower urinary tract symptoms with schizophrenia and its treatments: A narrative review

Schofield,

Taylor,

Drake

2023

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…In this context, it would be interesting to make a mention of a paper reporting a possible curative role of clozapine in neurogenic bladder. 12 This effect of clozapine was observed in a patient with schizophrenia. However, resolution of urinary incontinence in this case was found to be unrelated to the clinical response for schizophrenia.…”

mentioning

confidence: 88%