Clozapine-Induced Priapism

Rosen, Scott I.; Hanno, Philip M.

doi:10.1016/s0022-5347(17)36751-4

Cited by 32 publications

(14 citation statements)

References 16 publications

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“…It is of note that both drugs tend not to produce marked increases in prolactin, in common with clozapine, which, together with quetiapine and aripiprazole, is truly prolactin-sparing. Clozapine has been found to be associated with low levels of sexual dysfunction compared with typical antipsychotics, although there have been reports of priapism with this drug (Rosen 1992;Seftel 1992, Compton 2000.…”

Section: Atypical Antipsychotic Medicationsmentioning

confidence: 99%

Sexuality in psychosis: dysfunction, risk and mental capacity

Smith

Herlihy²

2011

Adv. psychiatr. treat

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SummaryIssues such as sexual dysfunction, hypersexuality, risky sexual behaviour and mental capacity in relation to sexual activities arise frequently in people with psychosis. However, they may not always be given a priority in doctor-patient interactions, despite their often critical importance from the patient's perspective. Having a working knowledge of these topics may improve the quality of psychiatric intervention for people with severe mental illness. This article explores these topics, with a particular emphasis on assessment and management in everyday practice.

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Section: Atypical Antipsychotic Medicationsmentioning

confidence: 99%

Sexuality in psychosis: dysfunction, risk and mental capacity

Smith

Herlihy²

2011

Adv. psychiatr. treat

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“…However, there are case reports of retrograde ejaculation and priapism with clozapine, risperidone and olanzapine (Rosen & Hanno, 1992;Emes & Milson, 1994;Deirmenjian et al, 1998;Compton et al, 2000;Songer & Barclay, 2001).…”

Section: Sexual Side-effects Of Atypical Antipsychoticsmentioning

confidence: 99%

Sexual side-effects of antidepressant and antipsychotic drugs

Baldwin¹,

Mayers

2003

Adv. psychiatr. treat

151

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Adequate sexual expression is essential to many human relationships and provides a sense of physical, psychological and social well-being. Epidemiological and clinical studies show that depression and schizophrenia are associated with impairment of sexual function and satisfaction, even in untreated patients. Most antidepressant and antipsychotic drugs have adverse sexual effects but it is difficult accurately to identify the incidence of treatment-emergent dysfunction, as disturbances can be reliably detected only from systematic enquiries made at baseline and during treatment. Growing awareness of the adverse effects of psychotropic drugs has led to attempts to use adjuvants or substitute treatments to resolve sexual dysfunction. More studies of the effects of antidepressant and antipsychotic drugs on sexual function are needed. AbstractThe normal sexual response is conventionally divided into the four phases listed below, and disorders can occur at one or more of these phases.(1) Desire: typically this consists of fantasies about, and the desire to have, sexual activity. (2) Excitement: a subjective sense of sexual pleasure and accompanying physiological changes, namely penile tumescence and erection in men and pelvic vasocongestion, swelling of the external genitalia, vaginal lubrication and expansion in women. (3) Orgasm: this is when sexual pleasure peaks, with release of sexual tension and rhythmic contraction of the perineal muscles and reproductive organs. In men, the sensation of ejaculatory inevitability is followed by ejaculation of semen. In women, contractions of the outer third of the vaginal wall occur. (4) Resolution: a sense of muscular relaxation and general well-being. Men are physiologically refractory to erection and orgasm for a variable period after orgasm, whereas women may respond to further stimulation.The ICD-10 (World Health Organization, 1992) uses the term 'sexual dysfunction' to cover the ways in which an individual is unable to participate in a sexual relationship as he or she would wish. This classification has 10 subdivisions (F52.0-F52.9), each describing different forms of dysfunction. The DSM-IV (American Psychiatric Association, 1994) uses a similar scheme. Whenever possible, doctors should specify which form of sexual dysfunction is present, as these have differing causes and require different treatment approaches.Some types of dysfunction occur in both men and women, although women tend to present with complaints about the subjective quality of sexual experience (e.g. lack of desire), whereas men often describe the failure of a specific response (such as erection) but a continuing sexual desire. Epidemiology of sexual dysfunctionThis area has not been studied extensively. Nathan (1986) evaluated 22 studies of sexual behaviour in the general population but concluded that methodological problems in the surveys meant that only broad estimates could be made. The prevalence of inhibited sexual desire was 16% for men, 35% for women; for erectile dysfunction and premature ejacul...

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“…Veno-occlusive priapism or low flow leads to vessel-stasis, hypoxia, ischemia and acidosis, resulting in irreversible cavernosa fibrosis (Compton & Miller, 2001;Seftel et al, 1992;Dormin & Schmidt, 1976). In brief, treatment is as follows: Intra-caverosal washing, followed by intracavernosal injection of an a-agonist, and in case none is effective, shunt surgery between corpora covernosa and corpus spongiosium, otherwise sapheo-caverno surgery is suggested (Rosen & Hanno, 1992;Seftel et al, 1992;Emes & Millson, 1994;Maizel et al, 1996;Tekell et al, 1995;Nicolson & McCurley, 1997;Diermenjian et al, 1998;Patel, Mukherji, & Lee, 1996). Impotence was reported in more than 50% of the cases in which priapism was not treated (Compton & Miller, 2001;Segraves, 1989;Thompson et al, 1990;Rosen & Hanno, 1992;Seftel et al, 1992;Emes & Millson, 1994;Maizel et al, 1996;Tekell et al, 1995;Nicolson & McCurley, 1997;Diermenjian et al, 1998;Patel et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Among serotonine-dopamine antagonist (SDA) it was observed more with clozapine, risperidone and olanzapine (Compton & Miller, 2001;Rosen & Hanno, 1992;Seftel et al, 1992;Rogeogs & de Alwls, 1986). Until February 2003, it was not reported in patients using quetiapine and ziprasidone (Compton & Miller, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Antipsychotic agents were implicated in 15% to 26% of priapism associated with medications (Thompson, Ware, & Blashfield, 1990). Among atypical antipsychotic, Clozapine, Risperidone and Olanzapine have been reported to be associated with priapism as well (Rosen & Hanno, 1992;Seftel, Saenz de Tejada, & Szetela, 1992;Emes & Millson, 1994;Maizel, Umansky, & Knobler, 1996;Tekell, Smith, & Silva, 1995;Nicolson & McCurley, 1997;Diermenjian, Erhart, & Wirshing, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Priapism Associated with Risperidone: A Case Report

Hosseini¹,

Rostami²,

Esmaeli³

2006

Int J Ment Health Addiction

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Background & objective: Priapism is a rare but serious adverse effect of psychotrpic drugs where antipsychotic agents were implicated in 15% to 26% of priapism associated with medications. Among atypical antipsychotic, clozapine, risperidone and olanzapin have been reported to be associated with the condition. Case report: The patient was a 24 years old man referred to the OPD clinic with symptoms of delusion of control, delusion of persecution, delusion of somatic and auditory hallucination, and since last year had progressive non-sexual stimulation and painful erection. Conclusion: Physicians who prescribe serotonine-dopamine antagonist (SDA) should be careful about this rare yet serious complication, especially in cases with previous history of priapism following the use of psychotropic drugs.

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Clozapine-Induced Priapism

Cited by 32 publications

References 16 publications

Sexuality in psychosis: dysfunction, risk and mental capacity

Sexuality in psychosis: dysfunction, risk and mental capacity

Sexual side-effects of antidepressant and antipsychotic drugs

Priapism Associated with Risperidone: A Case Report

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