Clozapine injected into the nucleus accumbens potentiates apomorphine-induced jaw movements

Anatomical connections of the ventral, but not the dorsal part of the striatum with the parvicellular reticular formation: Implications for the anatomical substrate of oral movements

“…The present study was guided by the outcome of the pharmacological studies performed in the same laboratory (4,5,12). This approach had the advantage that the anatomical experiments could be matched with the earlier reported pharmacological experiments in all aspects.…”

“…It is unknown whether this vlSNR also projects to the RF. in this context, it is relevant to note that the dmS appears to play only a regulatory role in the expression of oral movements (4,5,12): it does certainly not play a critical role in the generation of these movements, since direct activation or blockade of dopamine D1 and/or D2 receptors in the dmS cannot elicit oral movements (4). These pharmacological data suggest that the vlS and the dmS are differentially connected with the RF.…”

“…The injections (0.05 -0.1 u\) were made with glass micropipettes (tip diameter, 20 -30 ^.m) attached to a 1 ¡A syringe filled with either 2.5 % PHA-L (Vector Lab., Burlingame, CA) or 1 % CTB (Vector Lab., Burlingame, CA) in 0.01 M sodium phosphate-buffered saline (PBS, pH 8.0 for PHA-L and pH 7.3 for CTB, respectively). The coordinates for the dmS and vlS were based on our above-mentioned pharmacological studies (4,5,12) (16). After 14 days of survival, the rats were given an overdose of sodium pentobarbitone (80 mg/kg i.p.)…”