2023
DOI: 10.3389/fpsyt.2023.1123246
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Clozapine prescription rates in Southeast Europe: A cross-sectional study

Abstract: IntroductionInternational reports indicate that clozapine is under prescribed. Yet, this has not been explored in Southeast European (SEE) countries. This cross-sectional study investigates clozapine prescription rates in a sample of 401 outpatients with psychosis from Bosnia and Herzegovina, Kosovo by United Nations resolution, North Macedonia, Montenegro and Serbia.MethodsDescriptive analysis was used to explore clozapine prescription rates; daily antipsychotic dosage was calculated and converted into olanza… Show more

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Cited by 5 publications
(2 citation statements)
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“…Although clozapine is clinically indicated for approximately 30% of patients with TRS, prescription rates were lower than expected for high-income countries and the use of nontherapeutic doses ( 36 , 37 ). In our study, clozapine was only prescribed to 4.5% of participants, whereas Massuda et al.…”
Section: Discussionmentioning
confidence: 88%
“…Although clozapine is clinically indicated for approximately 30% of patients with TRS, prescription rates were lower than expected for high-income countries and the use of nontherapeutic doses ( 36 , 37 ). In our study, clozapine was only prescribed to 4.5% of participants, whereas Massuda et al.…”
Section: Discussionmentioning
confidence: 88%
“…Although CLO is mainly used in monotherapy, it is sometimes also used in combination with other drugs. In this year’s cross-sectional South-Eastern European study 70.5% of patients received CLO in polytherapy ( Russo et al, 2023 ). The findings of our study suggest that, based on the pharmacokinetic and pharmacodynamic properties and the potential interactions of CLO, the use of one or two additional psychotropic drugs does not have to be associated with a high risk of toxicity.…”
Section: Discussionmentioning
confidence: 99%