2020
DOI: 10.5152/tjg.2015.150379
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Clues to the diagnosis of biliary atresia in neonatal cholestasis

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Cited by 17 publications
(13 citation statements)
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“…One study reported an accuracy level of 85% for GGT levels above 300 U/L when BA presented before 10 weeks of age; another study reported a sensitivity of 83.1%, a specificity of 98.1%, and an accuracy level of 65.6% for γ-GT levels above 300 U/L. [2] In this study, there was a statistically significant difference in the γ-GT levels between the BA and non-BA groups. We found that GGT at a cut-off value above 180 U/L exhibited a sensitivity of 87.1%, a specificity of 67.0%, a PPV of 57.7%, an NPV of 91.0%, and an accuracy level of 73.9% for differentiating BA and non-BA cases.…”
Section: Discussionmentioning
confidence: 64%
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“…One study reported an accuracy level of 85% for GGT levels above 300 U/L when BA presented before 10 weeks of age; another study reported a sensitivity of 83.1%, a specificity of 98.1%, and an accuracy level of 65.6% for γ-GT levels above 300 U/L. [2] In this study, there was a statistically significant difference in the γ-GT levels between the BA and non-BA groups. We found that GGT at a cut-off value above 180 U/L exhibited a sensitivity of 87.1%, a specificity of 67.0%, a PPV of 57.7%, an NPV of 91.0%, and an accuracy level of 73.9% for differentiating BA and non-BA cases.…”
Section: Discussionmentioning
confidence: 64%
“…In newborns and infants, biliary atresia (BA) is still a challenge for clinicians and researchers. [2] Diagnosis of BA at an early stage is of great clinical importance, while misdiagnosis may result in treatment failure and even death. [3,4] In contrast, a significant proportion of neonatal cholestasis (NC) cases do not have BA, and there is unnecessary laparotomy for them.…”
Section: Introductionmentioning
confidence: 99%
“…The utility of ultrasonography, as an initial diagnostic modality has been established in several studies. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] However, there was controversy in the existing literature while there was no such local published material which necessitated the present study.…”
Section: Discussionmentioning
confidence: 99%
“…Biliary atresia (BA), a destructive, inflammatory cholangiopathy affecting both the intra- and extrahepatic bile ducts, is the cause of death in children within 2 years of life due to biliary cirrhosis and liver failure if the Kasai procedure is not performed early in life [ 1 , 2 ]. The incidence of BA varies among different populations, ranging from 1 in 5–10,000 live births in Taiwan [ 3 ] and Japan [ 4 ] to about 1 in 15–20,000 in mainland Europe [ 5 ], England, Wales [ 6 ] and North America [ 7 ].…”
Section: Introductionmentioning
confidence: 99%