Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials

Kasper, Siegfried; Dienel, Angelika

doi:10.1007/s00213-002-1203-2

Cited by 37 publications

(1 citation statement)

References 32 publications

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“…So far, DTW has only been used to study unipolar depression, 14,15,20,21 but no study has focused solely on BD. To our best knowledge, only two cross‐sectional network studies examined mood symptoms in BD 22,23 .…”

Section: Introductionmentioning

confidence: 99%

Dynamic time warp analysis of individual symptom trajectories in individuals with bipolar disorder

et al. 2023

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BackgroundManic and depressive mood states in bipolar disorder (BD) may emerge from the non‐linear relations between constantly changing mood symptoms exhibited as a complex dynamic system. Dynamic Time Warp (DTW) is an algorithm that may capture symptom interactions from panel data with sparse observations over time.MethodsThe Young Mania Rating Scale and Quick Inventory of Depressive Symptomatology were repeatedly assessed in 141 individuals with BD, with on average 5.5 assessments per subject every 3–6 months. Dynamic Time Warp calculated the distance between each of the 27 × 27 pairs of standardized symptom scores. The changing profile of standardized symptom scores of BD participants was analyzed in individual subjects, yielding symptom dimensions in aggregated group‐level analyses. Using an asymmetric time‐window, symptom changes that preceded other symptom changes (i.e., Granger causality) yielded a directed network.ResultsThe mean age of the BD participants was 40.1 (SD 13.5) years old, and 60% were female participants. Idiographic symptom networks were highly variable between subjects. Yet, nomothetic analyses showed five symptom dimensions: core (hypo)mania (6 items), dysphoric mania (5 items), lethargy (7 items), somatic/suicidality (6 items), and sleep (3 items). Symptoms of the “Lethargy” dimension showed the highest out‐strength, and its changes preceded those of “somatic/suicidality,” while changes in “core (hypo)mania” preceded those of “dysphoric mania.”ConclusionDynamic Time Warp may help to capture meaningful BD symptom interactions from panel data with sparse observations. It may increase insight into the temporal dynamics of symptoms, as those with high out‐strength (rather than high in‐strength) could be promising targets for intervention.

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Section: Introductionmentioning

confidence: 99%

Dynamic time warp analysis of individual symptom trajectories in individuals with bipolar disorder

et al. 2023

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Current Awareness in Human Psychopharmacology

2003

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Herbaceuticals: An Overview for Counselors

Ingersoll

2005

Journal of Counseling &Amp; Development

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As more and more people are using unregulated herbaceuticals worldwide, counselors need to be alert to the types of herbs clients may be taking; the effects, side effects, and drug interactions associated with different herbaceuticals; and the ethical implications of treating a client who is taking herbaceuticals. This article provides an overview of the psychological, physiological, cultural, and legal issues associated with herbaceuticals and introduces some of the emerging ethical issues.

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Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials

Cited by 37 publications

References 32 publications

Dynamic time warp analysis of individual symptom trajectories in individuals with bipolar disorder

Dynamic time warp analysis of individual symptom trajectories in individuals with bipolar disorder

Current Awareness in Human Psychopharmacology

Herbaceuticals: An Overview for Counselors

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