Cluster headache and other TACs: Pathophysiology and neurostimulation options

Láinez, Miguel J. A.; Guillamón, Edelmira

doi:10.1111/head.12874

Cited by 39 publications

(36 citation statements)

References 87 publications

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“…Another single-center, long-term follow-up (1-8-year) study revealed that 8 out of 16 drugresistant CCH patients became asymptomatic with bilateral ONS, whereas 2 patients changed from the chronic to episodic subtype, and 4 out of 16 patients showed more than 50% improvement in the reduction of the number of headache attacks. The frequent AEs were electrode migration, battery replacement, and local infection [119].…”

Section: Single-center Studies Of Implantable Ons In Chmentioning

confidence: 99%

Therapeutic strategies that act on the peripheral nervous system in primary headache disorders

Tajti

Delia

Nyári

et al. 2019

Expert Review of Neurotherapeutics

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Introduction: Acute and preventive treatment of primary headache disorders is not completely resolved with regard to efficacy, safety, and tolerability. Hence, peripheral and central neuromodulation can provide therapeutic alternatives in drug-resistant cases. Peripheral targets of neuromodulation include invasive and non-invasive neurostimulation and electrical and chemical nerve and ganglion blockades. Areas covered: A PubMed search of papers published from January 2012 to October 2018 was conducted. The goal of this review was to analyze the efficacy and safety of invasive (implantable) peripheral neurostimulation methods (the occipital nerve, the cervical branch of vagal nerve, the sphenopalatine ganglion) and non-invasive (transcutaneous) peripheral neurostimulation methods (the occipital nerve, the supraorbital nerve, and the cervical and auricular branches of the vagal nerve), based on the results of published clinical trials and case series. Acting also on the peripheral nervous system, peripheral nerve (i.e. greater occipital nerve) and ganglion (i.e. sphenopalatine ganglion) blockades, botulinum neurotoxin type A-hemagglutinin complex therapies, and calcitonin generelated peptide-related monoclonal antibody treatments in this patient population are also discussed. Expert opinion: This review summarizes the latest results on the therapeutic strategies acting on the periphery in primary headache disorders. These therapeutic options are minimally invasive or noninvasive, efficacious, safe, and well tolerated. ARTICLE HISTORY

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Section: Single-center Studies Of Implantable Ons In Chmentioning

confidence: 99%

Therapeutic strategies that act on the peripheral nervous system in primary headache disorders

Tajti

Delia

Nyári

et al. 2019

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

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“…Neuromodulatory treatment options, both invasive (brain stimulation, implantable nerve stimulators) and noninvasive (transcutaneous stimulators) have become available as an option to treat CH. 12 Deep brain stimulation for highly selected patients has been shown to be effective, but carries potentially serious risks. Recently, the Food and Drug Administration approved a hand-held vagal nerve stimulator to treat acute attacks of CH in those with episodic CH.…”

Section: Clinical Featuresmentioning

confidence: 99%

Cluster Headache and Other Trigeminal Autonomic Cephalalgias

McGeeney

2018

Semin Neurol

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The trigeminal autonomic cephalalgias are a group of distinct primary headache disorders that share common characteristics of strict unilateral headache often accompanied by unilateral cranial autonomic features. Cluster headache is the most well-known example, but other than neurologists, practitioners often have limited familiarity with these disorders and treatment options. Delays in diagnosis are typical and treatment options remain suboptimal, associated with limited scientific research into these brain disorders. Improved familiarity with core clinical features by health care providers should lead to earlier referral to specialists, and this education is the responsibility of headache medicine specialists. Optimistically, the last few years have seen lobbying for more federal research support in headache medicine and there has been renewed interest by private industry in potential new treatments for trigeminal autonomic cephalalgias.

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“…The method was initially developed for and applied to movement disorders in several target areas; such as the thalamus, the pallidum, and the subthalamic nucleus. It is currently being extended to other indications, such as epilepsy (Chan et al 2018;Hartl et al 2018;Lobato-Polo et al 2018;Son et al 2018), dystonia (Magown et al 2018;Takeda et al 2018), tremor (Moldovan et al 2017;Camalier et al 2018), cluster headache (Chabardès et al 2016;Láinez and Guillamón 2017), chronic pain, including pain from stroke (Lempka et al 2017;Gopalakrishnan et al 2018), amputation (Pereira et al 2013;Kuffler 2018), trigeminal neuralgia (Nizard et al 2012;Yamgoue et al 2016) and multiple sclerosis (Abboud et al 2017;Oliveria et al 2017), and recently to psychiatric disorders, such as obsessive compulsive disorder (Naesström et al 2017;Winter et al 2017;Franzini et al 2018), Tourette's syndrome (Marceglia et al 2017;Martinez-Ramirez et al 2018), and depression (Kringelbach et al 2007b). The mechanism of action will likely turn out to be quite complex, involving cell-firing inhibition, neurotransmitter depletion, jamming and excitation of inhibitory pathways that lead to functional inhibition, and mimicking the effects of lesioning of the stimulated structures (Benabid 2014).…”

Section: Invasive Brain Stimulationmentioning

confidence: 99%

Brain stimulation methods for pain treatment

Kvašňák

Rokyta²

2018

gpb

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Treatment of pain is one of the most important aims of medicine. Over the past several decades, invasive, semi-invasive and non-invasive brain stimulation methods have been tested and implemented for modulation of the pain. In this review, we bring an overview of those methods including stimulation of both deep brain structures utilizing invasive and semi-invasive techniques and the brain cortex stimulated by non-invasive transcranial magnetic and electrical techniques. Another potentially beneficial method that could modulate pain by stimulating the deep brain with interferential transcranial alternating current is discussed as well.

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Cluster headache and other TACs: Pathophysiology and neurostimulation options

Cited by 39 publications

References 87 publications

Therapeutic strategies that act on the peripheral nervous system in primary headache disorders

Therapeutic strategies that act on the peripheral nervous system in primary headache disorders

Cluster Headache and Other Trigeminal Autonomic Cephalalgias

Brain stimulation methods for pain treatment

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