Cluster of Pseudomonas aeruginosa catheter-related bloodstream infections traced to contaminated multidose heparinized saline solutions in a medical ward

Prospero, Emilia; Barbadoro, Pamela; Savini, Sara; Manso, Esther; Annino, I.; D’Errico, Marcello Mario

doi:10.1016/j.ijheh.2006.05.002

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…A culture from an open, supposedly sterile saline bottle grew B. circulans, which suggests possible breaches in infection control. Multidose heparin and saline vials have been reported as the cause of outbreaks of hepatitis C (23,24), S. marcescens (25), and Pseudomonas aeruginosa (26) infections.…”

Section: Discussionmentioning

confidence: 99%

Alcaligenes xylosoxidansBloodstream Infections in Outpatient Oncology Office

Kim

Bancroft

Lehnkering

et al. 2008

Emerg. Infect. Dis.

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In 2002, we investigated a cluster of patients with Alcaligenes xylosoxidans bloodstream infections by conducting a matched case-control study and a prospective study. Pulsed-fi eld gel electrophoresis (PFGE) was performed on blood culture isolates, and 1 explanted central venous catheter (CVC) was tested for biofi lm. We identifi ed 12 cases of A. xylosoxidans bloodstream infection. Case-patients were more likely than controls to have had a CVC (7/7 [100%] vs 4/47 [8.7%], respectively; p<0.0001). Ten case isolates were indistinguishable by PFGE analysis, and A. xylosoxidans biofi lm from the CVC matched the outbreak strain. We observed multiple breaches in infection control, which may have caused contamination of multidose vials used to fl ush the CVCs. Our study links A. xylosoxidans with CVC biofi lm and highlights areas for regulation and oversight in outpatient settings.

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Section: Discussionmentioning

confidence: 99%

Alcaligenes xylosoxidansBloodstream Infections in Outpatient Oncology Office

Kim

Bancroft

Lehnkering

et al. 2008

Emerg. Infect. Dis.

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“…Liquid or moist pharmaceuticals can cause or maintain outbreaks (37,85,89,90,103) as can moist cosmetics and water (35,42,67,70,84,92,99,103,104). Even transplanted organs can transmit bacteria like P. aeruginosa and cause an outbreak (58).…”

Section: Outbreaks Caused By Medical Devicesmentioning

confidence: 99%

An Outbreak of Pseudomonas aeruginosa Infection Caused by Contaminated Mouth Swabs

Iversen

Jacobsen

Eriksen

et al. 2007

Clinical Infectious Diseases

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“…En la literatura médica se ha reportado brotes de P. aeruginosa causados por diversos procedimientos médicos, incluyendo broncoscopio contaminado, colangio-pancreatografía retrógrada endoscópica y cistoscopia [2][3][4] . La contaminación de soluciones salinas multidosis heparinizadas ha sido demostrada como fuente ambiental de bacteriemias nosocomiales 5 . La coronariografía (angiografía coronaria-AC) es un procedimiento seguro pero invasor, utilizada comúnmente para tanto diagnóstico como tratamiento de una enfermedad coronaria 6 .…”

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