Cluster polyanions and surface-covered complexes: From synergistic self-assembly to bio-functionalization

Wang, Gengxin; Guan, Weiming; Li, Bao; Wu, Lixin

doi:10.1016/j.cocis.2018.01.016

Cited by 19 publications

(7 citation statements)

References 86 publications

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“…[15] The surface of POM clusters is easily modified by cationic organic surfactants, biomolecules, and polymers via electrostatic interaction to construct novel nanostructured materials. [16] Biocompatible polymer nanocomposites integrating POMs were designed as multiple platforms for enhanced magnetic resonance imaging, pH-response chemotherapy, and on-site activated photothermal therapies. [17,18] Dual-crosslinked dynamic hydrogel that incorporates wheel-shaped POM {Mo 154 } and doxorubicin is efficient for synergistic photothermal and chemotherapy applications.…”

Section: Research Articlementioning

confidence: 99%

Surface Engineering Promoted Insulin‐Sensitizing Activities of Sub‐Nanoscale Vanadate Clusters through Regulated Pharmacokinetics and Bioavailability

Chen

Liu

Zhu

et al. 2022

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The therapeutic application of vanadium compounds is plagued by their poor bioavailability and potential adverse effects. Herein, 1 nm polyoxovanadate (POV) clusters are functionalized with alkyl chains of various lengths and studied for the effect of surface engineering on their preclinical pharmacokinetics and typical insulin‐sensitizing activity. The concentrations of surface engineered POVs in plasma, urine, and feces are monitored after a single administration to rats. The POVs exhibit a two‐compartment profile of in vivo kinetics, and the surface engineering effect plays an important role in renal clearance of the POVs comparable to small molecules. POVs functionalized with long alkyl chains show much shorter elimination half time t1/2β and higher elimination fractions (50%) within 48 h than pristine POVs, suggesting favorable elimination kinetics to mitigate the possible side effects of vanadium. Meanwhile, long alkyl chain modification leads to a 76% increment of oral bioavailability in contrast to unmodified POVs. As suggested by glucose tolerance tests and sub‐chronic toxicity tests, the above two factors contribute to the enhanced therapeutic efficacy of POVs while mitigating their adverse effects. The surface engineering protocol provides a feasible approach to the optimization of the bioavailability and pharmacokinetic properties of POVs for promoted insulin‐sensitizing activities.

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Section: Research Articlementioning

confidence: 99%

Surface Engineering Promoted Insulin‐Sensitizing Activities of Sub‐Nanoscale Vanadate Clusters through Regulated Pharmacokinetics and Bioavailability

Chen

Liu

Zhu

et al. 2022

Small

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“…POMs, consisting of early transition metal (W, Mo, or V) bridged by oxygen, are a class of nanosized inorganic polyanions with rigid topology, various constituents and remarkable properties, such as multielectronic redox activity, photo-or electrochromic properties, and luminescence. [224,225] In particularly, POMs have attracted growing research interests due to their unique potentials in the development of inorganic drugs, such as antitumor, viral, bacterial activity.. [226][227][228] In this regard, the integration of POMs with biomolecules has garnered well-deserved attention. [229][230][231][232][233] On one hand, the POMs have the capacity to tune the structures and functions of biomolecules.…”

Section: Cationic Peptides and Polyoxometalatesmentioning

confidence: 99%

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Xie

Zheng

2020

Macromol. Rapid Commun.

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innovative insight into understanding the properties of the material systems beyond molecular level. [6-8] Through the last decades, supramolecular chemistry has deeply permeated and fused with biology and materials science, and has gradually growth into an interdisciplinary platform for the creation of self-assembled systems with extraordinary properties. [9-12] Among the numerous systems, self-assembled peptide is one of the most important branches, because of its rich chemical diversity, versatile characters, inherent biocompatibility, and bioactivity. [13-15] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [16-22] and important biofunctions, such as drug delivery, [23-25] tissue engineering, [26-28] regenerative medicine, [29-31] and biomineralization. [32-35] Moreover, many studies have disclosed that self-assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself. [36-42] For those reasons, peptide self-assembly has been recognized as a subject of great importance in supramolecular chemistry, biology, and nanotechnology, and the breadth and depth of peptide selfassemblies have been documented and demonstrated in several excellent reviews. [43-51] Besides the self-assembly of unimolecular peptides, multicomponent coassembly between peptides and other building blocks has recently become increasingly prevalent, as the modular approach offers a simple and effective way to arrive at supramolecular materials with wide structural complexity and value-added properties for multiple tasks applications. [52-56] This integrated characteristic further stimulates researchers to explore the scope of peptide coassembly with the aim of expanding the space of functional utility. To selectively form the multicomponent nanostructures, the interplay of the driving forces should be energetically much more favorable for strengthening the coassembly of distinct components than the self-sorting of the same type of components. [57-59] Following this design criteria, the introduction of complementary noncovalent interactions into the multicomponent systems is Peptide assembly has been extensively exploited as a promising platform for the creation of hierarchical nanostructures and tailor-made bioactive materials. Ionic coassembly of cationic peptides and anionic species is paving the way to provide particularly important contribution to this topic. In this review, the recent progress of ionic coassembly soft materials derived from the electrostatic coupling between cationic peptides and anionic species in aqueous solution is systematically summarized. The presentation of this review starts from a brief background on the general importance and advantages of peptide-based ionic coassembly. After that, divers...

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“…[1] POMs are polyanionic nanoclusters comprised of early transition metal (Mo, W, V, Nb, Ta) oxides bridged by oxygen atoms. [2,3] Owing to their rich structures, abundant surface groups, and tunable compositions, POMs are attractive in many applications including catalysts, [4] electronic devices, [3,5] photovoltaic materials, [6] and biomedical applications. [2,7,8] One special structure of molybdenum POMs is giant nanoclusters with more than 100 Mo atoms.…”

Section: Introductionmentioning

confidence: 99%

Molybdenum Blues with Tunable Light Absorption Synthesized by Femtosecond Laser Irradiation of Molybdenum Trioxide in Water/Ethanol Mixtures

Ayub

Chang

et al. 2022

Advanced Optical Materials

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Molybdenum blues (MBs) have attracted increasing attention due to their tunable structures and properties, which make them applicable in numerous fields. In this work, a novel strategy to synthesize MB nanorings by irradiating MoO3 suspended in water/ethanol mixtures with intense femtosecond laser pulses is demonstrated. It is found that the MoO3 can be dissolved in the water during laser irradiation to form molybdic acid, which provides an acidic environment for the formation of MB. Concentrations of ethanol as low as 1% result in the formation of MB and by adjusting the concentration of ethanol in the solvent, the absorption band can be tuned due to the modification of MoVOMoVI entities. The MB synthesized in 30% ethanol appears the darkest blue and assembly of vesicles 115 nm in size is observed. At high concentrations of ethanol (>70%), HXMoO3 and MoO3‐X are preferentially formed instead of MB. The photothermal conversion efficiency of the MBs synthesized in 1% and 30% ethanol is above 40%.

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Cluster polyanions and surface-covered complexes: From synergistic self-assembly to bio-functionalization

Cited by 19 publications

References 86 publications

Surface Engineering Promoted Insulin‐Sensitizing Activities of Sub‐Nanoscale Vanadate Clusters through Regulated Pharmacokinetics and Bioavailability

Surface Engineering Promoted Insulin‐Sensitizing Activities of Sub‐Nanoscale Vanadate Clusters through Regulated Pharmacokinetics and Bioavailability

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Molybdenum Blues with Tunable Light Absorption Synthesized by Femtosecond Laser Irradiation of Molybdenum Trioxide in Water/Ethanol Mixtures

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