Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
Lawrence J. Dooling,
Alişya A. Anlaş,
Michael P. Tobin
et al.
Abstract:Macrophages often pervade solid tumors, but their nearest neighbor organization is understudied and potentially enables key functions such as phagocytosis. Here, we observe dynamic macrophage clusters in tumors under conditions that maximize cancer cell phagocytosis and use reductionist approaches to uncover pathways to cluster formation and roles for tumor-intrusive pseudopodia, which we term 'intrudopodia'. Macrophage clusters form over hours on low-adhesion substrates after M1 polarization with interferons,… Show more
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