Clustered Organization of Krüppel Zinc-Finger Genes at Xp11.23, Flanking a Translocation Breakpoint at OATL1: A Physical Map with Locus Assignments for ZNF21, ZNF41, ZNF81, and ELK1

Long-range map of a 3.5-Mb region in Xp11.23-22 with a sequence-ready map from a 1.1-Mb gene-rich interval.

“…Second, both regions were subcloned in colinear and longer (>300 kb) YACs Boycott et al 1996), which correspond typically to regions of normal gene density. In contrast, preliminary analysis of cosmids and small YACs located between the genes ELK1 (Rao et al 1989) and ZNF81 (Knight et al 1994) as well as between DXS1039 and DXS255 indicate a relatively gene-rich region with an average distance of 50 kb, approximately twice as dense as the mean for the entire X chromosome. with a gene, then 20-30 additional genes can be expected to map in this region, making a total of at least 40 genes in 1000 kb at an average distance of at most 25 kb.…”

“…A YAC contig encompassing the distal part of the Xp11.23 region between the loci TIMP and OATL1 has been published Knight et al 1994). A zinc-finger gene cluster has been detected on the distal OATL1 YAC (ICRFy900C0874; Knight et al 1994), which also contains breakpoints for synovial sarcomas (De Leeuw et al 1993;Chand et al 1995) and the retinal-expressed sequences MG61, MG81, MG21, and MG44 on the proximal OATL1 YAC (ICRFy900F0501; Geraghty et al 1993). Other YAC contigs encompassing the region between TIMP and the WASP gene locus also have been reported (Derry et al 1994;Fisher et al 1995;Kwan et al 1995a).…”

Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity

“…15 Several disease genes have been mapped to this region. They include the androgen receptor gene, 16 the XH2 gene, responsible for ATRX syndrome, an X-linked disorder comprising severe psychomotor retardation, genital abnormalities, and alpha-thalassaemia, 17 three genes responsible for eye diseases, [18][19][20] Wiskott-Aldrich syndrome, 21 one form of synovial sarcoma, 22 X-linked nephrolithiasis, 23 and zinc finger genes (ZXDA 24 and four Kruppel type 25 ). These zinc finger genes could be considered candidates for the syndrome described in this paper, and possibly the Wilson syndrome, further supported by earlier findings, showing that disruption of zinc finger genes was involved in human development disorders such as Greig-cephalopolysyndactyly syndrome 26 and Wilms tumour.…”

Genetic alterations in microdissected prostate cancer cells by comparative genomic hybridization

“…Chromosome X harbors the protooncogenes ELK1 (a member of ets-oncogene family) and RAFA1. 22 Chromosome 8 contains the MYC oncogene at 8q24 and its over-expression is well known in prostate cancer. 23,24 Ampli®cation was noted near chromosome 8q21 in our study, indicating that this region may harbor tentative oncogene(s) in prostate cancer.…”