Clusterin, an Abundant Serum Factor, Is a Possible Negative Regulator of MT6-MMP/MMP-25 Produced by Neutrophils

Matsuda, Akira; Itoh, Yoshifumi; Koshikawa, Naohiko; Akizawa, Toshifumi; Yana, Ikuo; Seiki, Motoharu

doi:10.1074/jbc.m301509200

Cited by 53 publications

(52 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MT6-MMP is expressed in neutrophils and in some brain tumours, and seems to play a vital role in neutrophil function. 27 However, the MMPs are responsible for the degradation of most components of the extracellular matrix, and the MT6-MMP specifically produced by neutrophils are believed to be important for invasion and migration of cells to inflammatory sites, and/or destruction of host tissue. 27 The importance of CLU expression for tissue remodelling and apoptosis has not only been demonstrated in malignancies but also in other models of cell growth and tissue remodelling, including in hair growth.…”

Section: Clu Cell Matrix Formation Cell Membrane Remodelling and Mmentioning

confidence: 99%

“…27 However, the MMPs are responsible for the degradation of most components of the extracellular matrix, and the MT6-MMP specifically produced by neutrophils are believed to be important for invasion and migration of cells to inflammatory sites, and/or destruction of host tissue. 27 The importance of CLU expression for tissue remodelling and apoptosis has not only been demonstrated in malignancies but also in other models of cell growth and tissue remodelling, including in hair growth. 28 The hair follicle goes through cycles of growth, regeneration, and rest that involve tissue remodelling and apoptosis.…”

Section: Clu Cell Matrix Formation Cell Membrane Remodelling and Mmentioning

confidence: 99%

See 1 more Smart Citation

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

et al. 2005

View full text Add to dashboard Cite

Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is proapoptotic, and a secretory form (sCLU) is prosurvival. CLU expression has been associated with tumorigenesis of various malignancies, including tumours of prostate, colon, and breast. Furthermore, CLU expression is modulated by many factors that are believed to regulate tumour growth and/or apoptosis, including 1,25-dihydroxyvitamin D 3 , transforming growth factor beta-1, ultraviolet radiation, and IR. sCLU upregulation appears to be a general molecular stress response. Presently, preliminary results indicate that therapeutic modalities targeting CLU may be effective in cancer treatment. However, such strategies should make sure that nCLU is not eliminated or reduced. This review summarizes our present understanding of the importance of CLU in various physiological functions including tumour growth, and discusses its relevance to future cancer therapy.

show abstract

Section: Clu Cell Matrix Formation Cell Membrane Remodelling and Mmentioning

confidence: 99%

Section: Clu Cell Matrix Formation Cell Membrane Remodelling and Mmentioning

confidence: 99%

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

et al. 2005

View full text Add to dashboard Cite

show abstract

“…These features make the MT1-MMP associations with C1q distinct from those reported for MT6-MMP/neutrophil-specific leukolysin and clusterin. Clusterin, a major component of serum, forms an inhibitory complex with MT6-MMP and plays the role of a negative regulator of the activity of the protease produced by neutrophils (47).…”

Section: Discussionmentioning

confidence: 99%

Non-proteolytic, Receptor/Ligand Interactions Associate Cellular Membrane Type-1 Matrix Metalloproteinase with the Complement Component C1q

Rozanov

Sikora

Godzik

et al. 2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs)1 constitute a family of zinc enzymes that are capable of cleaving a wide range of extracellular matrix proteins and soluble and cell surface-associated regulatory proteins (1). MT1-MMP, a prototypic member of a membrane-anchored MMP subfamily, is distinguished from soluble MMPs by the existence of a C-terminal transmembrane domain that associates the protease with the lipid membrane bilayer and a cytoplasmic tail that interacts with the intracellular milieu (2). Currently, six membrane-type MMPs are known: MT1-, MT2-, MT3-, MT4-, MT5-and MT6-MMP (1). In contrast to the soluble MMPs, MT1-MMP is ideally positioned for regulating pericellular proteolysis (3, 4). Our prior studies and the results of other investigations have revealed a key role for MT1-MMP in carcinogenesis and malignancy and demonstrated that MT1-MMP is a likely centerpiece of malignant transformation and that MT1-MMP contributes directly to tumor cell migration, invasion, and metastasis (5-9). Proteolysis of matrix alone, however, does not fully explain the important and unique role of MT1-MMP in tumor growth and malignant progression and, in particular, in metastasis.

show abstract

“…They are able to degrade several components of the extracellular matrix, their common substrates are gelatin, fibronectin, chondroitine sulfate and dermatan sulfate. MT6-MMP can also cleave type IV collagen, fibrin, fibrinogen, α1 proteinase inhibitor (α1Pi) [56,57]. In addition to these matrix substrates, MT-MMPs are able to cleave other signaling molecules such as cell surface receptors, growth factors, growth factor binding proteins, cytokines/chemokines [3] (Table 1).…”

Section: Substrates Of Mt-mmpsmentioning

confidence: 99%

Membrane type-matrix metalloproteinases and tumor progression

2005

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-MMPs) are a recently discovered subgroup of intrinsic plasma membrane proteins. Their functions have been extended from pericellular proteolysis and control of cell migration to cell signaling, control of cell proliferation and regulation of multiple stages of tumor progression including growth and angiogenesis. This review sheds light on the new functions of MT-MMPs and their inhibitors in tumor development and angiogenesis, and presents recent investigations that document their influence on various cell functions.

show abstract

Clusterin, an Abundant Serum Factor, Is a Possible Negative Regulator of MT6-MMP/MMP-25 Produced by Neutrophils

Abstract: MT6-MMP/MMP-25 is

Cited by 53 publications

References 37 publications

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

Non-proteolytic, Receptor/Ligand Interactions Associate Cellular Membrane Type-1 Matrix Metalloproteinase with the Complement Component C1q

Membrane type-matrix metalloproteinases and tumor progression

Contact Info

Product

Resources

About