Clustering in canine malignant lymphoma

Abstract

A clustering of generalized malignant lymphoma is reported in a single household of Rottweiler dogs (both parents and three of the four sibling in one litter) and in a breeding pair of unrelated Scottish terriers. In addition, malignant lymphoma of the myocardium was found in three directly related otterhounds (the sire and two sibling offspring). Possible genetic and viral factors in the aetiology of canine malignant lymphoma are discussed.

Canine malignant lymphoma: A review and comparison with human non‐hodgkin's lymphoma

“…The breed predisposition discussed above suggests that NHL has a genetic basis, or is somehow related to an inherited characteristic (11). This is also supported by the occurrence of familial aggregation of NHL in bull mastiffs (18), Rottweilers (19), and otterhounds (19), although aggregation of a disease in a family may also indicate influences of environmental or infectious factors.…”

Use of the Argyrophilic Nucleolar Region Method for Cytologic and Histologic Examination of the Lymph Nodes in Dogs

“…16,17,25,26,29 The increase of AgNOR frequency in lymphoma cases compared with the controls may be due to enhanced proliferation and the associated increased requirement for RNA synthesis. 6,7,16,19 In samples from healthy dogs examined in this study, the mean nuclear AgNOR counts using histologic processing fell within the range of 1.23-1.53 AgNORs per nucleus, which is similar to the value of 1.2 and 1.5 reported for humans by Yekeler et al 32 and Fig.…”

“…31 The clinical diagnosis for each lymphoma case was based on routine clinical, ultrasonographic, X-ray, bone marrow cytologic, and histopathologic examinations. 8,9,12,13,25,31 The final histopathologic diagnosis of the lymph nodes of patients with lymphoma was based on the guidelines described by Valli et al 32 Control samples were taken from 10 healthy Beagle dogs (six female and four male dogs), aged 1.5-2 years, under the supervision of the Local Ethical Committee of the Faculty of Veterinary Science, Szent István University, in accordance with the guidelines of the Guide to the Care and Use of Laboratory Animals (US Department of Health and Human Services, 1996).…”

“…Canine malignant lymphoma resembles human non-Hodgkin's lymphoma of high-grade malignancy. 9,25 Some authors have mentioned the possible role of pesticides and magnetic fields as etiologic factors, 31 and in certain cases, fa-milial predisposition has also been suggested. 25,31 Several forms or types of lymphoma are distinguished.…”

Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma

“…In addition, the standard deviation of the mean age was smaller for Golden Retrievers than for all other dogs, underscoring that age of onset is more similar within this single high-risk breed than when all dogs are considered together. Other evidence to support the existence of strongly embedded (albeit complex) heritable risk factors for this disease in dogs can be inferred by familial clustering observed in Bull mastiff, Rottweiler and Scottish Terrier lines, 10,11 and by the fact that breed also can influence response to therapy. 5 The breed predisposition for NHL in dogs extends to specific phenotypes ('B cell' and 'T cell').…”