Clustering of<i>Mycobacterium tuberculosis</i>Cases in Acapulco: Spoligotyping and Risk Factors

Nava-Aguilera, Elizabeth; López-Vidal, Yolanda; Harris, Eva; Morales-Pérez, Arcadio; Mitchell, Steven; Flores-Moreno, Miguel; Villegas-Arrizón, Ascencio; Legorreta-Soberanis, José; Ledogar, Robert J.; Andersson, Neil

doi:10.1155/2011/408375

Cited by 32 publications

(35 citation statements)

References 33 publications

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“…Four of our eight EAI isolates correspond to the ubiquitous and common SIT19 genotype and could also have originated from the Philippines, given the commercial links of that region with Mexico from 1565 to 1815 through the Manila-Acapulco galleon [33]. This hypothesis is consistent with the recent finding that one fourth of the M. tuberculosis isolates in Acapulco correspond to the EAI family [12], where the largest cluster has the SIT19 genotype previously found in Monterrey [11], and now by us in a cluster with four isolates.…”

Section: Discussionsupporting

confidence: 89%

“…Sociodemographic and clinical variables in the low incidence region are similar to those in Monterrey and Acapulco [11,12], two Mexican cities of relatively low marginalization. In contrast, such variables in the high incidence region resemble more those of highly marginal rural regions of the Mexican state of Chiapas [27] where the average age of PTB cases is around 40 years, whereas in the high incidence region of San Luis Potosí it is close to 53 years.…”

Section: Discussionmentioning

confidence: 86%

“…The Euro-American lineage of M. tuberculosis predominates in Mexico [11], where some areas also have high frequencies of the Indo-Oceanic lineage [12]. In Mexico M. bovis also appears to be a relevant cause of pulmonary TB (PTB) in humans [13,14], and the Beijing family of the M. tuberculosis East-Asian lineage has been mentioned in a recent paper [5].…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México

et al. 2013

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BackgroundAlthough epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis (TB) control in Mexico, molecular epidemiology studies of the disease in the country are scarce.MethodsComplete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB (PTB) cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex (MTC) isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined.ResultsPulmonary tuberculosis incidence ranged from 2.4 to 33.4 (cases per 100,000 inhabitants) in the six state sanitary jurisdictions that were grouped in regions of low (jurisdictions I-II-III), intermediate (jurisdictions IV-V) and high incidence (jurisdiction VI) with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis (104 spoligotypes in 24 clusters) and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage (Beijing family) in the capital city, the Indo-Oceanic (Manila family) in eastern localities, and M. bovis in rural localities.ConclusionsIn San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México

et al. 2013

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“…Similarly, 19% (23) of the population had a medical history of DM-2, coinciding with reports illustrating a high association of this co-morbidity within Mexico (Ponce-de-Leon et al 2004, Nava-Aguilera et al 2011, Pérez-Navarro et al 2011, Zenteno-Cuevas et al 2012, Cuevas-Córdoba et al 2013, Jiménez-Corona et al 2013). …”

Section: Discussionsupporting

confidence: 77%

Characterisation of pks15/1 in clinical isolates of Mycobacterium tuberculosis from Mexico

Zenteno-Cuevas

Silva-Hernández

Mendoza-Damián

et al. 2013

Mem. Inst. Oswaldo Cruz

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Tuberculosis (TB) is an infectocontagious respiratory disease caused by members of the Mycobacterium tuberculosis complex. A 7 base pair (bp) deletion in the locus polyketide synthase (pks)15/1 is described as polymorphic among members of the M. tuberculosis complex, enabling the identification of Euro-American, Indo-Oceanic and Asian lineages. The aim of this study was to characterise this locus in TB isolates from Mexico. One hundred twenty clinical isolates were recovered from the states of Veracruz and Estado de Mexico. We determined the nucleotide sequence of a ± 400 bp fragment of the locus pks15/1, while genotypic characterisation was performed by spoligotyping. One hundred and fifty isolates contained the 7 bp deletion, while five had the wild type locus. Lineages X (22%), LAM (18%) and T (17%) were the most frequent; only three (2%) of the isolates were identified as Beijing and two (1%) EAI-Manila. The wild type pks15/1 locus was observed in all Asian lineage isolates tested. Our results confirm the utility of locus pks15/1 as a molecular marker for identifying Asian lineages of the M. tuberculosis complex. This marker could be of great value in the epidemiological surveillance of TB, especially in countries like Mexico, where the prevalence of such lineages is unknown.

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“…In similar studies by Navaet al [23] in Acapulco, Mexico, using a different spatial method, clusters were not found. We used two search windows (50% and 25%) in order to find small clusters but identification differences were not seen in cluster identification.…”

Section: Discussionmentioning

confidence: 72%

Spatial and Temporal Distribution of Tuberculosis in the State of Mexico, Mexico

Zaragoza-Bastida

Téllez

Bustamante-Montes

et al. 2012

The Scientific World Journal

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Tuberculosis (TB) is one of the oldest human diseases that still affects large population groups. According to the World Health Organization (WHO), there were approximately 9.4 million new cases worldwide in the year 2010. In Mexico, there were 18,848 new cases of TB of all clinical variants in 2010. The identification of clusters in space-time is of great interest in epidemiological studies. The objective of this research was to identify the spatial and temporal distribution of TB during the period 2006–2010 in the State of Mexico, using geographic information system (GIS) and SCAN statistics program. Nine significant clusters (P < 0.05) were identified using spatial and space-time analysis. The conclusion is that TB in the State of Mexico is not randomly distributed but is concentrated in areas close to Mexico City.

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Clustering ofMycobacterium tuberculosisCases in Acapulco: Spoligotyping and Risk Factors

Cited by 32 publications

References 33 publications

Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México

Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México

Characterisation of pks15/1 in clinical isolates of Mycobacterium tuberculosis from Mexico

Spatial and Temporal Distribution of Tuberculosis in the State of Mexico, Mexico

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