Clustering of Multiple Endemic Strains of Methicillin-Resistant<i>Staphylococcus aureus</i>in a Nursing Home: An 8-Year Study

Drinka, Paul J.; Stemper, Mary E.; Gauerke, Cathy; Miller, Janice E.; Goodman, Brian; Reed, Kurt D.

doi:10.1086/502530

Cited by 20 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, a case of MRSA infection may follow a prolonged period of asymptomatic nasal colonization after an aspiration event or development of a necrotic wound. 115 Outbreaks in LTCFs accounted for a substantial proportion (15%) of reported epidemics 116 (Table 1). Clustering of URIs, diarrhea, skin and soft tissue infection, conjunctivitis, and antibiotic-resistant bacteriuria have been noted.…”

Section: Epidemic Infections In the Ltcfmentioning

confidence: 99%

SHEA/APIC Guideline: Infection prevention and control in the long-term care facility

Smith

Bennett²,

Bradley

et al. 2008

American Journal of Infection Control

204

132

View full text Add to dashboard Cite

Section: Epidemic Infections In the Ltcfmentioning

confidence: 99%

SHEA/APIC Guideline: Infection prevention and control in the long-term care facility

Smith

Bennett²,

Bradley

et al. 2008

American Journal of Infection Control

204

132

View full text Add to dashboard Cite

“…There have been case reports of not only vancomycin tolerance but also vancomycin resistance (3). This has an impact on the healthy population, with the growing incidence of communityacquired MRSA, and is of even more concern for the evergrowing number of elderly patients with numerous comorbid conditions, including hospitalized and nursing home patients (4,6,7,17). Numerous alternative regimens are being tested in this era of multidrug-resistant organisms.…”

mentioning

confidence: 99%

In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus

Singh¹,

Bacon²,

Young

et al. 2009

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

show abstract

“…However, there have been a few studies reporting the dynamics of MRSA over long periods of time (3,18,19,41,42,45,51). These studies showed that the molecular epidemiology of MRSA is evolving.…”

mentioning

confidence: 99%

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

et al. 2007

View full text Add to dashboard Cite

The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) at an international level shows that most MRSA strains belong to a few pandemic clones. At the local level, a predominance of one or two clones was generally reported. However, the situation is evolving and new clones are emerging worldwide, some of them with specific biological characteristics, such as the presence of Panton-Valentine leucocidin (PVL). Understanding these changes at the local and international levels is of great importance. Our objective was to analyze the evolution of MRSA epidemiology at multiple sites on a local level (Western Switzerland) over a period of 8 years. Data were based on MRSA reports from seven sentinel laboratories and infection control programs covering different areas. Pulsed-field gel electrophoresis was used to type MRSA isolates. From 1997 to 2004, a total of 2,256 patients with MRSA were reported. Results showed the presence of four predominant clones (accounting for 86% of patients), which could be related to known international clones (Berlin, New York/Japan, Southern Germany, and Iberian clones). Within the small geographic region, the 8-year follow-up period in the different areas showed spacio-temporal differences in the relative proportions of the four clones. Other international MRSA clones, as well as clones showing genetic characteristics identical to those of community-acquired MRSA (SCCmec type IV and the presence of PVL genes), were also identified but presumably did not disseminate. Despite the worldwide predominance of a few MRSA clones, our data showed that at a local level, the epidemiology of MRSA might be different from one hospital to another. Moreover, MRSA clones were replaced by other emerging clones, suggesting a rapid change.

show abstract

Clustering of Multiple Endemic Strains of Methicillin-ResistantStaphylococcus aureusin a Nursing Home: An 8-Year Study

Cited by 20 publications

References 12 publications

SHEA/APIC Guideline: Infection prevention and control in the long-term care facility

SHEA/APIC Guideline: Infection prevention and control in the long-term care facility

In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus

Changing Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in a Small Geographic Area over an Eight-Year Period

Contact Info

Product

Resources

About