Clustering of multiple sclerosis in the county of Hordaland, Western Norway

Larsen, Jan Petter; Riise, Trond; Nyland, Harald; Kvåle, Gunnar; Aarli, Johan A.

doi:10.1111/j.1600-0404.1985.tb03218.x

Cited by 24 publications

(5 citation statements)

References 18 publications

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“…The study also showed an uneven geographical distribution, with a gradient in prevalence decreasing from the eastern mountainous part of the region to the western areas closer to the coast. This is in line with other studies conducted at different latitudes, showing lower MS incidence in the coastal area compared to the inland area [ 32 , 33 ]. Diet and lifestyle factors have been hypothesized to modulate the risk of MS across regions at the similar latitude.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems

Bargagli¹,

Colais²,

Agabiti³

et al. 2016

J Neurol

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Compared with other areas of the country, very limited data are available on multiple sclerosis (MS) prevalence in Central Italy. We aimed to estimate MS prevalence in the Lazio region and its geographical distribution using regional health information systems (HIS). To identify MS cases we used data from drug prescription, hospital discharge and ticket exemption registries. Crude, age- and gender-specific prevalence estimates on December 31, 2011 were calculated. To compare MS prevalence between different areas within the region, we calculated age- and gender-adjusted prevalence and prevalence ratios using a multivariate Poisson regression model. Crude prevalence rate was 130.5/100,000 (95 % CI 127.5–133.5): 89.7/100,000 for males and 167.9/100,000 for females. The overall prevalence rate standardized to the European Standard Population was 119.6/100,000 (95 % CI 116.8–122.4). We observed significant differences in MS prevalence within the region, with estimates ranging from 96.3 (95 % CI 86.4–107.3) for Latina to 169.6 (95 % CI 147.6–194.9) for Rieti. Most districts close to the coast showed lower prevalence estimates compared to those situated in the eastern mountainous area of the region. In conclusion, this study produced a MS prevalence estimate at regional level using population-based health administrative databases. Our results showed the Lazio region is a high-risk area for MS, although with an uneven geographical distribution. While some limitations must be considered including possible prevalence underestimation, HIS represent a valuable source of information to measure the burden of SM, useful for epidemiological surveillance and healthcare planning.

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Section: Discussionsupporting

confidence: 93%

Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems

Bargagli¹,

Colais²,

Agabiti³

et al. 2016

J Neurol

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“…In Hordaland, also in coastal northwestern Norway, the mean annual incidence of MS was 2.5 per 100,000 population in 1958–1962 and the prevalence was 20 per 100,000 population on January 1, 1963 13 . The prevalence in Hordaland in 1963–1982 was also clustered and lower in the coastal area than in the inland area 14 .…”

Section: Resultsmentioning

confidence: 91%

Time trends in the incidence and prevalence of multiple sclerosis in N orway during eight decades

2015

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Norway has been subjected to numerous epidemiological investigations on the prevalence and incidence of multiple sclerosis (MS), dating back to 1935. The objective of this study was to review the studies on the prevalence and incidence of MS in Norway, provide an update on the prevalence of MS in Norway, and describe the time trends in the prevalence and incidence of MS in relation to risk factors, case ascertainment, and data. We performed a systematic search on PubMed and MEDLINE up to November 2014 using the search string ‘multiple sclerosis prevalence in Norway’ or ‘multiple sclerosis incidence in Norway’. In addition, we scrutinized the reference lists of the publications identified for relevant citations. We retrieved data on the distribution of MS in Norway on December 31, 2013 from the Norwegian Multiple Sclerosis Registry and Biobank and the Norwegian Patient Registry. We identified 29 articles. From 1961 to 2014, the reported prevalence of MS increased from 20 to 203 per 100,000 inhabitants, and the incidence increased from 1.9 to 8.0 per 100,000. The nationwide crude prevalence in Norway, based on the Norwegian Patient Registry, was 208 per 100,000 on December 31, 2013. The reported prevalence of MS in Norway has increased 10-fold, with several possible causes. During eight decades, neurological health services have generally become more accessible to the population, and transforming diagnostic criteria has made the diagnosis of MS more precise and valid. There have also been changes in lifestyle behavior and known risk factors, such as vitamin D and smoking, that might have contributed to the increased incidence of MS. A possible role of increased survival in MS needs to be examined further.This article is commented on by Berg-Hansen et al, published in 132: 364–367 (DOI: 10.1111/ane.12489).

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“…The incidence of MS in Hordaland County has in previous studies increased from 0.2/100 000 in 1935, 10 to 0.67/100 000 in 1951 11 and to 4.7/100 000 in 1978–1982. 9 However, in the present long-term follow-up study, we also identified patients with disease onset years prior and thus higher incidence rates of 1.8/100 000 during 1953–1957, 6.9/100 000 during 1978–1982 followed by a stable high level of approximately 7–8/100 000 during later years.…”

Section: Discussionmentioning

confidence: 87%

A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway

Grytten

Aarseth

Lunde

et al. 2015

J Neurol Neurosurg Psychiatry

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ObjectiveInvestigate the incidence of multiple sclerosis during 1953–2013 and estimate the prevalence rate of MS on 1 January 2003 and 2013 in Hordaland County, Western Norway.MethodsAll patients with onset of disease in Hordaland 1953–2013 were identified in files from previous studies until 2003 and from patient records at the departments of Neurology, Haukeland University Hospital and Haugesund Hospital during 2003–2013. 1558 patients were assessed and 1402 of these were included, of whom 1035 were alive and living in Hordaland at prevalence day 1 January 2013. Annual incidence rates were calculated for 1953–2013.ResultsOn 1 January 2003, the crude prevalence rate was 191/100 000 population and on 1 January 2013, the crude prevalence rate was 211.4 (95% CI 198.3 to 224.2) per 100 000; 270.9 (95% CI 250.6 to 292.3) for women and 151.8 (95% CI 136.8 to 167.9) for men. Prevalence peaked at ages 55–59 years for women and 60–64 years for men. The annual incidence rate increased from 1.9 (95% CI 1.2 to 2.6) per 100 000 during 1953–1957 to 7.2 (95% CI 6.0 to 8.5) during 1978–1982 and to 8.5 (95% CI 7.3 to 9.7) during 2003–2007, thus indicating a stabilising incidence over the past 35 years. The female/male ratio ranged from 1.2:1 to 1.8:1 (p=0.381) during the period.ConclusionsStabilising rather than increasing incidence combined with the stable female/male ratio are indicative of non-fluctuating environmental factors in a geographical area otherwise characterised by lack of vitamin D effective sun exposure. The rising prevalence of MS could result from improved survival and follow-up methodology.

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Clustering of multiple sclerosis in the county of Hordaland, Western Norway

Cited by 24 publications

References 18 publications

Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems

Prevalence of multiple sclerosis in the Lazio region, Italy: use of an algorithm based on health information systems

Time trends in the incidence and prevalence of multiple sclerosis in N orway during eight decades

A 60-year follow-up of the incidence and prevalence of multiple sclerosis in Hordaland County, Western Norway

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