Clusters of Arp2/3 Activators Mimic Pathogenic Actin Comets and Pedestals

Abstract

Ca 2þ loss from these intracellular stores, not from the extracellular space, we developed a flexible in vitro 3D skin equivalent model that allows intraorganelle monitoring of calcium levels by genetically encoded sensors. These new findings suggest that long-held hypotheses addressing Ca 2þ control of differentiation and barrier formation require revision.