Clusters of Infections in Horses with MRSA ST1, ST254, and ST398 in a Veterinary Hospital

Cuny, Christiane; Strommenger, Birgit; Witte, Wolfgang; Stanek, C

doi:10.1089/mdr.2008.0845

Cited by 110 publications

(117 citation statements)

References 24 publications

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“…Clonal complexes CC1 and CC8 were also observed in methicillin-resistant Staph. aureus (MRSA)-positive horses (Cuny et al, 2008;Walther et al, 2009), whereas CC9 was identified in pigs and pig farmers (Armand-Lefevre et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Alleles, ST, and clonal complexes (CC; groups of closely related ST) were assigned using the MLST database. Bovine-associated CC were distinguished from CC associated with other hosts based on the MLST database and literature (ArmandLefevre et al, 2005;Smith et al, 2005b;Aires-de-Sousa et al, 2007;Rabello et al, 2007;Cuny et al, 2008;Deurenberg and Stobberingh, 2008;Ikawaty et al, 2009;Walther et al, 2009;Hasman et al, 2010;Weese and van Duijkeren, 2010). Clonal complexes were defined to be bovine adapted if isolates belonging to those CC were frequently found in milk samples, and included CC50, CC97, CC151, and CC479.…”

Section: Genotypingmentioning

confidence: 99%

See 1 more Smart Citation

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Borne

Nielen

Schaik

et al. 2010

Journal of Dairy Science

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Staphylococcus aureus causes a wide range of diseases in multiple species. Some sequence types (ST) are observed in a variety of hosts, whereas other strains are mainly associated with bovine mastitis, suggesting host adaptation. We propose that host adaptation of Staph. aureus may influence bacteriological cure of bovine subclinical mastitis after antimicrobial treatment. To test this hypothesis, multilocus sequence typing was performed on Staph. aureus isolates from 60 treated and 79 untreated control quarters that were obtained from well-defined cohorts of dairy cows from a recently conducted randomized field trial on early treatment of subclinical mastitis. Bovine-associated ST were distinguished from non-bovine-associated ST based on the literature and public databases. The association between host adaptation and bacteriological cure was investigated using population-averaged logistic regression models. Thirteen ST were identified, with approximately 80% of isolates belonging to bovine-associated ST. The odds for cure were around 2.5 times as high for non-bovine-associated ST as for bovine ST in treated quarters, whereas no difference in spontaneous cure was observed in untreated control quarters. In addition, host adaptation was related to known predictors of cure, such as penicillin susceptibility and somatic cell count. All isolates belonging to non-bovine-associated ST were resistant to penicillin, whereas the majority of isolates belonging to bovine-associated ST were penicillin susceptible. Penicillin-resistant bovine-associated strains were associated with high somatic cell counts compared with other strains. The correlation between penicillin resistance, cell counts, and host adaptation may affect the association between host adaptation and cure. For diagnostic purposes, a simple and fast alternative to multilocus sequence typing of Staph. aureus to determine host adaptation may be valuable.

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Section: Discussionmentioning

confidence: 99%

Section: Genotypingmentioning

confidence: 99%

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Borne

Nielen

Schaik

et al. 2010

Journal of Dairy Science

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“…17,31,35,38,42 Specific MRSA belonging to clonal complexes CC1, CC5, CC8, CC22, CC59, CC88, CC398, and mainly to spa type t002, t008, t009, t011, t020, t022, t032, t034, t036, t064, t127, t166, t186, t216, t451, t588, t1197, t1451, and t2123 have been identified as a cause of nosocomial infections in numerous equine clinics. 9,27,[37][38][39]43 S. aureus can colonize the skin and mucosa, especially nasal mucosa, of healthy horses and humans, which then acts as a reservoir for MRSA and contributes to its spread into the community and hospitals. 14,35,38,40 Horses entering the hospital have been shown to contribute to the introduction and spread of MRSA in the clinic.…”

mentioning

confidence: 99%

Evolution of Multidrug-ResistantStaphylococcus aureusInfections in Horses and Colonized Personnel in an Equine Clinic Between 2005 and 2010

Sieber

Gerber

Jandova

et al. 2011

Microbial Drug Resistance

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“…Although the CC8-SCCmec IV genotype has been the most frequently found, CC398-SCCmec IV has recently become a major genotype. CC398-SCCmec IV was irst found from infected horses in the Veterinary University of Vienna in Austria [222]. CC398 isolated from nasal samples of horses in the Netherlands and Belgium exhibited high prevalence rates, 9.3 and 10.9%, respectively [227,229].…”

Section: Equine Mrsamentioning

confidence: 94%

“…Multidrugresistant ST8 MRSA was detected in Belgium, Germany, Swizerland, and the USA. A single locus variant of ST8 classiied as ST254 MRSA was isolated from horses in Austria, Germany, Ireland, and the UK [183,208,222,223]. Twelve diferent MLST types have been reported and most of the MRSA strains were grouped into the CC8 or CC398 classes [224].…”

Section: Equine Mrsamentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products

Chon¹,

Sung²,

Khan³

2017

Frontiers in Staphylococcus Aureus

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Methicillin-resistant Staphylococcus aureus (MRSA) has become a growing concern in companion and food-producing animals. The presence of multidrug-resistance with a wide range of extracellular enterotoxin genes, virulence factors, and Panton-Valentine leukocidin (pvl) cytotoxin genes confer life-threatening traits on MRSA and makes them highly pathogenic and diicult to treat. Clonal complex 398 (CC398), a predominant clonal lineage of livestock-associated-MRSA in domestic animals and retail meat, is capable of infecting humans. In order to monitor and prevent MRSA contamination, it is critical to understand its source and transmission dynamics. In this review, we describe MRSA in food-producing animals (pig, catle, chicken), horses, pet animals (dogs, cats), and food products (pork, beef, chicken, milk, and ish).

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Clusters of Infections in Horses with MRSA ST1, ST254, and ST398 in a Veterinary Hospital

Cited by 110 publications

References 24 publications

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Host adaptation of bovine Staphylococcus aureus seems associated with bacteriological cure after lactational antimicrobial treatment

Evolution of Multidrug-ResistantStaphylococcus aureusInfections in Horses and Colonized Personnel in an Equine Clinic Between 2005 and 2010

Methicillin-Resistant Staphylococcus aureus (MRSA) in Food- Producing and Companion Animals and Food Products

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