Infective endocarditis is an uncommon disease carrying a mortality between 10% and 25%. The mitral and aortic valves are involved between 34-42% and 36-50% respectively. Early and aggressive treatment is mandatory, this impacts on early and long-term outcomes. A multi-disciplinary team approach is currently accepted as standard of practice. Approximately half of the patients require cardiac surgery as a part of the treatment. In case of extravalvular spread of infection, persistent sepsis, multiple embolic events despite appropriate antibiotic therapy, acute or worsening conduction abnormalities or heart failure, urgent surgery must be considered. When the infection involves the aortic root, a radical approach is preferred. As we expected, prosthetic valve endocarditis has worst outcomes, particularly related to the higher mortality in reoperations.