“…CMOS chips are ideal candidates for miniaturization of point of care devices for sample identification, imaging, signal processing, and readout. [32][33][34][35] However, we leverage here only the existing patterned surface of the CMOS chip decorated with a few, larger 7 mm polystyrene beads. By pouring PDMS on top of this surface, we fabricate, via soft lithography, an innovative PDMS substrate consisting of nano-and microbowl structures.…”