CMOS multiplexer for portable biosensing system with integrated microfluidic interface

Voitsekhivska, Tetiana; Suthau, Eike; Wolter, K.-J.

doi:10.1109/ectc.2014.6897285

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Generally, the mainboard contains electronics for conditioning, supplying, and acquisition purposes. Analog-to-digital converters (ADC) and digital-to-analog converters (DAC) are connected to a microcontroller unit (MCU), so that the system allows for controlled application of voltages to biochip via a triple 32:1 complementary metal-oxide-semiconductor -integrated analogue multiplexer. − The main board also contains the USB interface for communication purposes with a PC and a power supply. The exact layout and description of the functional parts are presented in Figure C.…”

Section: Resultsmentioning

confidence: 99%

Nanosensor-Based Real-Time Monitoring of Stress Biomarkers in Human Saliva Using a Portable Measurement System

et al. 2020

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Small molecules with no or little charge are considered to have minimal impact on signals measured by field effect transistor (FET) sensors. This fact typically excludes steroids from the family of analytes, detected by FETs. We present a portable multiplexed platform based on an array of nanowire sensors for label-free monitoring of daytime levels of the stress hormone cortisol in saliva samples, obtained from multiple donors. To achieve an effective quantification of the cortisol with FETs, we rely on the specific DNA aptamer sequences as receptors, bringing the complex "target-receptor" closer to the nanowire surface. Upon binding, cortisol induces conformational changes of negatively charged aptamers, wrapping it into a close proximity to the silicon nanowires, to efficiently modulate their surface potential. Thus, the sensors allow for a real-time assessment of the steroid biomarkers at low nanomolar concentration. The measurement platform is designed in a building-block concept, consisting of a modular measuring unit and a customizable biochip board, and operates using a complementary metal-oxide-semiconductor-integrated multiplexer. The platform is capable of continuous and simultaneous measurement of samples from multiple patients. Cortisol levels detected with the presented platform agreed well with the results obtained with a commercial high-sensitivity immunoassay.

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Section: Resultsmentioning

confidence: 99%

Nanosensor-Based Real-Time Monitoring of Stress Biomarkers in Human Saliva Using a Portable Measurement System

et al. 2020

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“…Tetiana et al built an analog multiplexer consisting of 96 analog transfer gates and 32 shift registers with serial interface control pins for data acquisition from a SiNW (Silicon NanoWire) FET-based biosensor, as shown in Figure 6a-b. [19] The system was found to deliver sensitive, accurate, and fast measurements, where 32 integrated multiplexers had less than 10 nA leakage currents. [100] CMOS helps realize portable systems for the study of membrane protein, which is currently limited by the bulkiness of existing tools.…”

Section: Data Processorsmentioning

confidence: 99%

“…Signal acquisition from a large array of sensors to a single system requires a complex integration scheme, but CMOS microfabrication processes enable the integration of analogue multiplexers with biosensors on small dice. [19] CMOS also has the capability to actuate pumps and valves in microfluidic devices or to directly influence the fluid itself using electric and magnetic forces, thereby replacing the bulky pressure-driven positive displacement pumps. [20][21][22][23] CMOS technologies have the ability to fabricate such actuators and corresponding control circuitry on a single chip.…”

Section: Introductionmentioning

confidence: 99%

Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

et al. 2018

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In article number https://doi.org/10.1002/adma.201705759, Muhammad M. Hussain and co‐workers present a comprehensive review on the role of CMOS technology for advanced microfluidics‐based personalized healthcare applications. The advanced and reliable CMOS technology offers a miniaturization opportunity to integrate a broad spectrum of devices involving sensors, actuators, and definitely integrated circuits with standard microfluidic components and operations such as flow cytometry, polymerase chain reaction (PCR) tests, immunoassays, and blood chemistry with an overarching objective: affordability.

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“…On the other hand, utilizing bulk flow to propagate information-carrying molecules through a fluid medium to an intended receiver may not be suitable for applications where inducing a flow of the medium itself is problematic, unwanted, or even impossible (e.g., in lab-on-a-chip applications employing microfluidics with highly parallel arrays of reactors in which inlet and outlet ports must be shared among many chip components [16]). Utilizing electric fields to controllably propagate information-carrying molecules is a potential method to resolve this limitation, rather than relying on fluid movement.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Molecular Communication with Time-Varying Electric Fields

Cho,

Sykes,

Coon

et al. 2021

Preprint

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This article investigates a novel electrophoretic molecular communication mechanism that utilizes a time-varying electric field, which induces time-varying molecule velocities and in turn improves communication performance. For a sinusoidal field, we specify favorable signal parameters (e.g., phase and frequency) that yield excellent communication link performance. We also analytically derive an optimized field function by formulating an appropriate cost function and solving the Euler-Lagrange equation. In our setup, the field strength is proportional to the molecular velocity; we verify this assumption by solving the Basset-Boussinesq-Oseen equation for a given time-varying electric field (forcing function) and examining its implications for practical physical parameterizations of the system. Our analysis and Monte-Carlo simulation results demonstrate that the proposed time-varying approach can significantly increase the number of information-carrying molecules expected to be observed at the receiver and reduce the bit-error probability compared to the constant field benchmark.

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CMOS multiplexer for portable biosensing system with integrated microfluidic interface

Cited by 6 publications

References 6 publications

Nanosensor-Based Real-Time Monitoring of Stress Biomarkers in Human Saliva Using a Portable Measurement System

Nanosensor-Based Real-Time Monitoring of Stress Biomarkers in Human Saliva Using a Portable Measurement System

Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

Electrophoretic Molecular Communication with Time-Varying Electric Fields

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