CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review

Li, Jie; Wang, Xiaozi; Wang, Xiaoning; Liu, Yan; Zheng, Nanning; Xu, Ping; Zhang, Xianghong; Xue, Liang

doi:10.2147/cmar.s358963

Cited by 3 publications

(3 citation statements)

References 115 publications

(119 reference statements)

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“…Furthermore, angiogenesis and the recruitment of immune cells are also linked to CMTM family members [ 10 , 11 ]. Additionally, previous studies have revealed that the expression and prognostic roles of CMTM family members are quite different in various tumors [ 12 ]. For instance, overexpression of CKLF was detected in HCC and was associated with poor survival in HCC patients [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma

Huang

Luo

et al. 2023

Current Oncology

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The Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family, comprising nine members, is involved in the tumorigenesis and progression of various cancers. However, the expression profiles and clinical significance of CMTM family members in hepatocellular carcinoma (HCC) are not fully clarified. In this study, the RNA-sequencing and clinical data were downloaded from The Cancer Genome Atlas (TCGA) databases. The Kaplan–Meier method and the Cox proportional hazards regression analysis were used to evaluate the prognostic significance of CMTM family members. Single-sample gene set enrichment analysis (ssGSEA) and ESTIMATE algorithms were employed to explore the relationship between CMTM family genes and the tumor microenvironment in HCC. Finally, the prognostic CMTM family gene expression was further validated by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical (IHC) staining in clinical HCC tissue specimens. The results indicated that, compared with normal tissues, the expression of CKLF, CMTM1, CMTM3, CMTM4, CMTM7, and CMTM8 were significantly upregulated in HCC, while the expression of CMTM2, CMTM5, and CMTM6 were significantly downregulated in HCC. Univariate and multivariate Cox regression analysis demonstrated that CKLF was an independent prognostic biomarker for the overall survival (OS) of HCC patients. In HCC, the expression of CKLF was found to be correlated with immune cell infiltration, immune-related functions, and immune checkpoint genes. The qRT-PCR and IHC confirmed that CKLF was highly expressed in HCC. Overall, this research suggested that CKLF is involved in immune cell infiltration and may serve as a critical prognostic biomarker, which provides new light on the therapeutics for HCC.

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Section: Introductionmentioning

confidence: 99%

CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma

Huang

Luo

et al. 2023

Current Oncology

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“…In particular, CMTM proteins play a critical role in the progression of tumors such as HCC, glioma cancer, non-small cell lung carcinoma, and breast cancer (Figure 1). [8][9][10][11][12] In this review, we summarized the current developments between HCC and the CMTM family.…”

Section: Introductionmentioning

confidence: 99%

“…10,18,19 Additionally, the CMTM family also contributes significantly to the pathogenesis of various cancers such as HCC, gliomas, non-small cell lung carcinoma, breast cancer. [8][9][10][11][12]…”

Section: Introductionmentioning

confidence: 99%

Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

Pei,

Zhang,

Tan

2023

JHC

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Hepatocellular carcinoma (HCC) is a typically malignant tumor in the digestive system. The mortality of HCC ranks third place in the world, second only to lung cancer and colorectal cancer. For the characteristics of high invasiveness, high metastasis, high recurrence rate as well as short survival time, HCC treatment has always been difficult in clinical practice. Many causes have contributed to the appearance of these features, including insidious onset, high degree of malignancy, lack of effective early molecular diagnostic markers, and disease prediction models. The human chemokine-like factor superfamily (CMTMs) is a new gene family consisting of CKLF and CMTM1-CMTM8. CMTMs have a marvel domain which can activate and chemotaxis immune cells. Many studies have reported that CMTMs are involved in the regulation of cell growth and development, and play an important role in the malignant progression of the immune system and reproductive system, especially in the development of tumors. In this review, we summarized the structure and function of the human CMTMs, the relationship between its family members and HCC, the prognostic value, potential functions, and mechanisms in HCC. CMTMs could provide a new diagnostic and therapeutic target in clinical practice for patients with HCC.

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Current advancements in PD-L1 modulation by CMTM6 in malignant tumors

Zhang,

He,

et al. 2024

Oncologie

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The CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6), a member of the chemokine-like factor superfamily, binds to programmed death-ligand 1 (PD-L1) on the cell membrane, thereby impeding PD-L1’s lysosomal degradation and sustaining its expression. In recent years, extensive studies on PD-L1 have provided insights into its function as an immunepoint inhibitor involved in tumor cell immune evasion. The specific interaction between CMTM6 and PD-L1 suggests a potential role in tumor cell immune evasion and suppression, potentially offering a novel therapeutic target for cancer immunotherapy. Currently, the research on CMTM6 and PD-L1 in diverse tumors and diseases is limited, but their significant roles are indicated. This article provides an overview of the impact of CMTM6 on the immune microenvironment in different types of cancer (such as lung cancer, breast cancer, and liver cancer), and summarizes the effects of CMTM6 on the occurrence and development of various tumors.

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CMTM Family and Gastrointestinal Tract Cancers: A Comprehensive Review

Cited by 3 publications

References 115 publications

CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma

CKLF as a Prognostic Biomarker and Its Association with Immune Infiltration in Hepatocellular Carcinoma

Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

Current advancements in PD-L1 modulation by CMTM6 in malignant tumors

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