Introduction: The novel coronavirus also called SARS-COV-2 was declared a global pandemic by the WHO in March 2020. In the Republic of Congo, the first imported case was introduced on March 14, 2020. Pointe-Noire, whose 1st case was reported on March 17, 2020, is described as the second epicenter of the disease after Brazzaville the capital. Objective: In this work, the authors described the epidemiological, diagnostic and therapeutic aspects that contributed to the management of COVID-19 patients in Pointe-Noire. Material and Method: This was a cross-sectional descriptive study. The situational analysis was based on the situation report (SITREP) n°: 434 including COVID-19 data from the department of Pointe-Noire since the declaration of the first case until June 19, 2021, a period of 15 months. The biological diagnosis was exclusively based on RT-PCR from a nasopharyngeal swab. The extraction was carried out using two processes: filter column extraction and magnetic ball extraction using different kits. Amplification was performed on five types of PCR instruments.