CNI-free immunosupression using everolimus in long term heart transplant recipients -procedures of switching protocols and side effects

Proliferation signal inhibitors in cardiac transplantation

“…The vast majority of studies showed that renal function improves after introducing a PSI and lowering or discontinuing CNIs. On average, a decrease in serum creatinine of 25-66% was seen [30,35,36,[40][41][42][43]. A few small studies have shown improvement in dialysis-dependent patients such that dialysis was no longer necessary [31,32].…”

Everolimus: an update on the mechanism of action, pharmacokinetics and recent clinical trials

“…Various reports, most with few cases, have evaluated the combination of PSIs with dose-reduced CNI on renal function in HTP. Some studies aimed for CNI dose reduction [107][108][109][110] and others for withdrawal [110][111][112][113][114][115][116][117] after initiating SRL or EVL. The majority of studies showed that renal function improves after introducing a PSI and lowering or discontinuing CNIs.…”