CNS Activity of &lt;I&gt;Jussiaea suffruticosa&lt;/I&gt; Linn. Extract in Rats and Mice

Murugesan, T.; Ghosh, L. K.; Das, J.; Pal, Mahesh; Saha, Basudeb

doi:10.1211/146080899128734334

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…The behavioral study of the animals was evaluated by EPM. The EPM test is based on a premise where the exposure to an EPM evoked an approach avoidance conflict that was considerably stronger than that evoked by the exposure to an enclosed arm (Murugesan et al, 1999;Guaraldo et al, 2000). The decrease in aversion to the open arm is the result of an anxiolytic effect expressed by the increase time spent and entries in the open arm.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Panda¹,

Panda²,

Panda³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMERYThe present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and antiinflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether (60 -80°C) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Panda¹,

Panda²,

Panda³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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“…For all test, Group-1 served as controls, Group-2 for standard and Group-3, Group-4 received experimental plant extract. Group 1 received the vehicle 1% Tween 80 in water (at the dose of 10 ml/kg body weight), group 2 received various standard drugs like Diazepam, Indomethacin, Aspirin at different doses [22][23][24], and group 3 and 4 received 200-400 mg/kg dose of plant extract on the basis of toxicity study of the plant extract.…”

Section: Experimental Designmentioning

confidence: 99%

Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Bhattacharjee¹,

Waqar²,

Barua³

et al. 2018

Clin Phytosci

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Background: Lathyrus sativus L. (Fabaceae) has long been used as a traditional medicine for the treatment of several ailments such as Scabies, eczema, and allergy. The aim of the study was to evaluate the phytochemical nature with Central Nervous System (CNS) depressant, analgesic, antipyretic activities of the methanolic plant extract of Lathyrus sativus L. seeds in different experimental models. Methods: Preliminary phytochemical screening and proximate analysis was carried out using different standard methods. CNS depressant activity was evaluated observing the effects of plant extract on Swiss albino mice using open field and hole-cross method. Acetic acid induced writhing and formalin induced paw licking methods were used for the appraisal of analgesic activity while 2,4-dinitrophenol (DNP) induced pyrexia model was used to investigate the antipyretic activity. The data were analyzed by one way ANOVA followed by Dunnett's test using SPSS (version 20). Results: The phytochemical analysis revealed the presence of wide range of phytoconstituents in the plant extract. Our investigation demonstrated that the methanolic plant extract significantly (p < 0.001) decreased the locomotor activity of mice in open field and hole-cross method at both the tested doses (200 and 300 mg/kg) which were comparable to the standard drug diazepam (1 mg/kg). The plant extracts significantly (p < 0.001) inhibited the writhing induced by acetic acid in mice to 87.09% and 80.65% (200 and 300 mg/kg respectively) compared to the standard indomethacin (70.97%). The extracts (200 and 300 mg/kg respectively) also significantly (p < 0.001) reduced the writhing to 43.39%, 64.15% in early and 46.15%, 97.44% in late phase of formalin-induced licking and biting. In 2,4-DNP induced pyrexia the extracts exhibited protection at 200 and 400 mg/kg, similar to standard drug aspirin at 150 mg/kg. Conclusion: The results demonstrated that the plant extract has potential CNS depressant, analgesic and antipyretic activity.

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“…The whole plant juice is also used as a diuretic. We have previously evaluated some of these activities in rats and mice (Murugesan et al 1999(Murugesan et al , 2000a. It has come to our notice that patients in the rural area of Tamilnadu (India) use the whole plant of J. suffruticosa, crushed with water and taken orally, for the treatment of diabetes.…”

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confidence: 99%

Anti-diabetic Activity of <I>Jussiaea suffruticosa</I> Extract in Rats

Murugesan¹,

Rao²,

S.³

et al. 2000

Pharmacy and Pharmacology Communications

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The hypoglycaemic and anti‐hyperglycaemic potential of a methanolic extract of Jussiaea suffruticosa Linn. (family‐Onagraceae) was evaluated in normal and alloxan‐diabetic rats. In normal rats, the methanolic extract of J. suffruticosa Linn. (200 and 400 mg kg−1) exhibited significant hypoglycaemic activity (P < 0.05) within 3 h after oral administration. The plasma glucose concentration was 89.83±6 mg/100 mL (control 115.5±3.6 mg/100 mL) at 3h and 78.16±5.7 mg/100 mL (control 113.2±4.2 mg/100 mL) at 4.5 h after oral administration of 400 mg kg−1 of the methanolic extract. The effect was prolonged up to 24 h and the plasma glucose concentration fell to 75.66±5.5 mg/100 mL (control 112.16±3.7 mg/100 mL). The effect was dose‐dependent. In alloxan‐diabetic rats, the methanolic extract (400 mg kg−1) showed a significant anti‐hyperglycaemic effect (P < 0.05) from 1.5 h after oral administration. This effect was prolonged up to 24 h and the plasma glucose concentration fell to 173.66±6 mg/100 mL (control 296.67±4.9 mg/100 mL) compared with 166.83±6.7 after oral administration of 10 mg kg−1 glibenclamide (standard). The results indicate that the methanolic extract of whole plants of J. suffruticosa Linn. has potent hypoglycaemic potential in normoglycaemic rats and alloxan‐diabetic rats.

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CNS Activity of <I>Jussiaea suffruticosa</I> Linn. Extract in Rats and Mice

Cited by 9 publications

References 4 publications

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models

Phytochemical and pharmacological evaluation of methanolic extract of Lathyrus sativus L. seeds

Anti-diabetic Activity of <I>Jussiaea suffruticosa</I> Extract in Rats

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