CNS-manifestation of aspergillosis in an extremely low-birth-weight infant

Baum, Heike von; Meth, Martina; Wellinghausen, Nele; Lindner, Wolfgang; Hummler, Helmut

doi:10.1007/s00431-006-0111-6

Cited by 12 publications

(2 citation statements)

References 30 publications

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“…Brain abscesses still have high rates of neurologic impairment and fatality2). While a number of reports have reviewed brain abscesses in adult populations, only a few comprehensive reports on long follow-ups of pediatric cases are available2-8). In this study, we analyzed data from 25 patients with brain abscesses and we describe the clinical features of these brain abscesses.…”

Section: Introductionmentioning

confidence: 99%

Brain abscess in Korean children: A 15-year single center study

et al. 2010

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PurposeA brain abscess is a serious disease of the central nerve system. We conducted this study to summarize the clinical manifestations and outcomes of brain abscesses.MethodsA retrospective chart review of pediatric patients diagnosed with brain abscesses from November 1994 to June 2009 was performed at Samsung Medical Center, Seoul, Korea.ResultsTwenty-five patients were included in this study. On average, 1.67 cases per year were identified and the median age was 4.3 years. The common presenting clinical manifestations were fever (18/25, 72%), seizure (12/25, 48%), altered mental status (11/25, 44%), and signs of increased intracranial pressure (9/25, 36%). A total of 14 (56%) patients had underlying illnesses, with congenital heart disease (8/25, 32%) as the most common cause. Predisposing factors were identified in 15 patients (60%). The common predisposing factors were otogenic infection (3/25, 12%) and penetrating head trauma (3/25, 12%). Causative organisms were identified in 64% of patients (16/25). The causative agents were S. intermedius (n=3), S. aureus (n=3), S. pneumoniae (n=1), Group B streptococcus (n=2), E. coli (n=1), P. aeruginosa (n=1), and suspected fungal infection (n=5). Seven patients received medical treatment only while the other 18 patients also required surgical intervention. The overall fatality rate was 16% and 20% of patients had neurologic sequelae. There was no statistical association between outcomes and the factors studied.ConclusionAlthough uncommon, a brain abscess is a serious disease. A high level of suspicion is very important for early diagnosis and to prevent serious consequences.

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Section: Introductionmentioning

confidence: 99%

Brain abscess in Korean children: A 15-year single center study

et al. 2010

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“…By comparison, there are very few reports about Aspergillosis except for sporadic cases of invasive pulmonary Aspergillosis (IPA), especially Aspergilloma. As the invasive Aspergillosis is a major threat for preterm infants due to high morbidity and mortality rates [2,3,4], the most important issue is an early diagnosis before dissemination and an appropriate choice of antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

A case of neonatal pulmonary Aspergillosis successfully treated with micafungin

Niwa

Kawai

Matsukura

et al. 2012

Journal of Neonatal-Perinatal Medicine

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Preterm infants are susceptible to opportunistic infection because of their immature immune system. As to fungal infection, Aspergillosis is second only to Candida infection in these patients. Here we report the case of an extremely low birth weight (ELBW) infant who developed pulmonary Aspergillosis and was successfully treated by micafungin (echinocandins). The infection occurred in the cavity in chronic lung disease and was diagnosed by typical CT imaging and detection of Aspergillus galactmannan antigen in the serum specimen. To our knowledge, this is the first report of pulmonary Aspergillosis treated with micafungin in ELBW infants.

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Infectious Diseases and Tropical Medicine

Al-Tubaikh

2023

Internal Medicine

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This work aimed at studying clinical parameters observed at admission and defervescence and serum ferritin levels measured at two states and their association with dengue severity and survival.-Patients and Methods: In a prospective, observational study conducted at a tertiary care center in central India, children aged 1 month-12 years of age, who were admitted in the hospital with a diagnosis of dengue fever (NS1 antigen or IgM/IgG status positive) and presenting within 84 hours of fever onset, were included. Clinical parameters and serum ferritin levels at admission and defervescences were recorded and measured. -Results: Between October 2018 and October 2020, 92 dengue-positive children were enrolled. The mean age was 6.58±3.50 years, and 56.5% were female. NS1 antigen positivity was seen in 89.1% of cases. Severe disease was seen in 12% of cases, whereas in-hospital mortality rate was 3.2%. Systolic and diastolic blood pressure, pulse pressure <20 mmHg, hepatomegaly, reduced urine output and bleeding manifestations identified on admission as well as in defervescence were associated with severity and mortality in children with dengue fever. Serum ferritin levels on admission and defervescence were also associated with dengue severity (p = 0.0001 and p = 0.0012, respectively) and in-hospital mortality (p = 0.0013 and p = 0.0151, respectively). -Conclusions: Clinical parameters and serum ferritin levels on admission and in defervescence are associated with severe dengue and can predict in-hospital mortality.

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CNS-manifestation of aspergillosis in an extremely low-birth-weight infant

Cited by 12 publications

References 30 publications

Brain abscess in Korean children: A 15-year single center study

Brain abscess in Korean children: A 15-year single center study

A case of neonatal pulmonary Aspergillosis successfully treated with micafungin

Infectious Diseases and Tropical Medicine

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