CNV rebound and aging

Tecce, Joseph J.; Cattanach, Lynn; Yrchik, Debra A.; Meinbresse, Debbie; Dessonville, Connie L.

doi:10.1016/0013-4694(82)90159-6

Cited by 19 publications

(17 citation statements)

References 13 publications

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“…The absence of age effects in the motor condition for the young-old is consistent with previous studies having mean ages in the older group of ∼65 years [16,24,66]. A study using somewhat older elderly subjects [39] (mean age = 72, range 64-91) reported reductions in CNV amplitude at a frontal site, which is similar to the finding of smaller CNV amplitudes at frontal sites in the oldest-old group relative to the young and young-old in the motor condition.…”

Section: Aging and The Contingent Negative Variation Componentsupporting

confidence: 91%

“…Thus, the study of the CNV could provide information relevant for defining the performance of neural networks that utilize structures differentially affected by aging. Previous studies that compared late CNV amplitudes in young and older subjects reported similar [16,24,66] or somewhat smaller [36,39] amplitudes for older relative to young subjects. In addition to examining CNV changes during old age, the present study also evaluated age differences as a function of task by contrasting conditions that did or did not require motor preparation.…”

Section: Introductionmentioning

confidence: 82%

“…Previous CNV studies comparing young and older subjects reported that CNV amplitudes before the imperative stimulus were similar [16,24,66] or somewhat smaller [36,39] in the older relative to young subjects. The absence of age effects in the motor condition for the young-old is consistent with previous studies having mean ages in the older group of ∼65 years [16,24,66].…”

Section: Aging and The Contingent Negative Variation Componentmentioning

confidence: 89%

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Event-related potentials accompanying motor preparation and stimulus expectancy in the young, young-old and oldest-old

Golob

Ovasapyan

Starr

2005

Neurobiology of Aging

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Although aging is accompanied by neurobiological changes and increased susceptibility to many neurological disorders, little is known about neurophysiological changes that start in old age. Here, neurophysiological changes during old age were assessed by recording brain potentials associated with motor preparation and stimulus expectancy (contingent negative variation, CNV) in young-old (60-69), oldest-old (85-98), and young (17-23) subjects. Individual trials began by a button press, followed 2.5 s later by either a low or high pitch tone. In the "motor" condition subjects responded following high pitch tones (P = 0.20); in the "non-motor" condition subjects did not respond. Motor condition CNV amplitudes in the oldest old were more positive than the young and young-old groups, which were similar. In the non-motor condition, the young-old and oldest-old had similar CNV amplitudes that were positive in polarity, and were significantly different from young subjects. Motor potentials before button presses that started the trials were comparable among groups. Results show that neural activity associated with motor preparation and stimulus expectancy changes during advanced age, and that group differences can be modulated by task requirements.

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Section: Aging and The Contingent Negative Variation Componentsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 82%

Section: Aging and The Contingent Negative Variation Componentmentioning

confidence: 89%

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Event-related potentials accompanying motor preparation and stimulus expectancy in the young, young-old and oldest-old

Golob

Ovasapyan

Starr

2005

Neurobiology of Aging

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“…This study measured the late CNV during two conditions to assess the effect of age on motor preparation and stimulus expectancy (motor condition) compared with stimulus expectancy alone (nonmotor condition). Similar to previous studies, late CNV amplitude was not significantly different between groups in either response condition (Dirnberger et al, 2000;Tecce et al, 1982), although older subjects had slightly smaller amplitude differences between motor and non-motor conditions for valid trials (see Fig. 9).…”

Section: Potentials Between Cues and Targetssupporting

confidence: 89%

Age-related differences in auditory event-related potentials during a cued attention task

Bennett¹,

Golob²,

Starr³

2004

Clinical Neurophysiology

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Objective: To determine if aging is associated with differences in attentional regulation using behavioral and event-related potential (ERP) measures.Methods: Younger (n ¼ 13; M ¼ 20 years) and older (n ¼ 12; M ¼ 76 years) subjects performed an auditory cued attention task. Verbal cues correctly (valid) or incorrectly (invalid) predicted the ear receiving a target tone 1.5 s later, or were uninformative (neutral). Targets were either 'high' (2000 Hz) or 'low' (1000 Hz) pitch monaural tones. Subjects pressed one of 4 buttons to indicate target ear and pitch. ERPs following cues and targets (P50, N100, P200, slow waves), and negative slow potentials (CNV) between cues and targets were assessed.Results: Cue information had significant effects on reaction time for both groups (valid , neutral , invalid). Target N100 amplitude was significantly affected by cueing in younger (invalid . valid) but not older subjects. Target slow waves were also affected by cue information (invalid . valid), and the difference was larger and lasted longer in older subjects. Slow waves following cues were significantly larger in older subjects, but the subsequent CNV amplitudes were comparable among groups.Conclusions: When performing a cued attention task, age differences are present in transient ERPs following cues and targets. Significance: Age differences in ERPs associated with attentional regulation support the hypothesis that attentional changes contribute to cognitive aging.

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“…physiological measure for the objective evaluation of variations in mental status associated with aging, dementia and other neurocognitive disorders. Amplitude reduction, espedally in centre-parietal areas, and higher mean latency of P3 to visual SI were found by Tecce et al [25,27] both in their eldec and oldest groups, tested with a simple con-220 stant foreperiod CNV-RT task. Lack of age differences in I"3 latency and significant reduction of P3 amplitude with increasing age were reported by Marsh [22] utilizing signaled tasks and speed instructions.…”

Section: Introductionmentioning

confidence: 68%

Age differences in contingent negative variation activity of healthy young adults and presenile subjects

et al. 1988

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20 selected right-handed very healthy subjects (10 young adults and 10 presenile subjects mean age 28.3 and 59.6) were tested for CNV activity with a simple warned reaction time (RT) paradigm. EEG and CNV components (post-S1, N1, P2, P3; early CNV; N1200; late CNV; CNV resolution) were recorded from Fz, C3, Cz, C4, P3, Pz, and P4 referenced to linked mastoid electrodes. EOG, RT and stimuli were also recorded. The presenile group differed significantly from the younger group in the auditory post-S1 N1 and P3, and in the early (O-wave) and late (P-wave) CNV complex components. A progressive amplitude reduction only in frontal leads between O-wave and P-wave with the lowest point being reached in the P-wave was characteristic in the presenile group. Further, presenile subjects showed relatively flat CNV waveshapes of low amplitude and, as a whole, performed a little less well than young persons. This finding suggests that the statistically significant changes in post-S1 EPRs and CNV activity recorded in our presenile subjects, without appreciable deficits in behavioral and mental performance, could be alerting signs of early brain involutional processes related to minimal and subclinical decrement of orienting, attentiveness and response preparation capabilities. If such is the case and it could be confirmed in a larger sample of very healthy subjects, these age-related changes in the presenium could be of considerable practical importance for clinical and research applications.

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CNV rebound and aging

Cited by 19 publications

References 13 publications

Event-related potentials accompanying motor preparation and stimulus expectancy in the young, young-old and oldest-old

Event-related potentials accompanying motor preparation and stimulus expectancy in the young, young-old and oldest-old

Age-related differences in auditory event-related potentials during a cued attention task

Age differences in contingent negative variation activity of healthy young adults and presenile subjects

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