2015
DOI: 10.4236/jct.2015.65044
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CNVs Associated with Susceptibility to Cancers: A Mini-Review

Abstract: Copy number variations (CNVs) that are frequent in genome influence on susceptibility of various diseases including cancers. The present mini-review focuses on CNVs associated with susceptibility to the cancers. Since CNVs are different between cancer types, the analysis of the specific CNV makes it possible to estimate the susceptibility to the cancers of interest in individuals. Although it is true that available data on CNVs associated with cancer susceptibility are limited at present, accumulation of the d… Show more

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Cited by 7 publications
(8 citation statements)
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“…We controlled for population stratification, applied filters which are stringent for CNV studies, and utilized 2 different CNV calling algorithms to ensure comprehensive detection of CNVs. Some of the reported CNV regions in this study were indeed characterized as disease conferring across a spectrum of phenotypes and therefore provide confidence in our study findings [Butler et al, 2005;Bailey et al, 2008;Diskin et al, 2009;Glessner et al, 2009Glessner et al, , 2010Ehli et al, 2012;Stadler et al, 2012;Lalani et al, 2013;Nagamani et al, 2013;Ukkola-Vuoti et al, 2013;Chettier et al, 2014;Szatkiewicz et al, 2014;Furuya et al, 2015].…”
supporting
confidence: 59%
“…We controlled for population stratification, applied filters which are stringent for CNV studies, and utilized 2 different CNV calling algorithms to ensure comprehensive detection of CNVs. Some of the reported CNV regions in this study were indeed characterized as disease conferring across a spectrum of phenotypes and therefore provide confidence in our study findings [Butler et al, 2005;Bailey et al, 2008;Diskin et al, 2009;Glessner et al, 2009Glessner et al, , 2010Ehli et al, 2012;Stadler et al, 2012;Lalani et al, 2013;Nagamani et al, 2013;Ukkola-Vuoti et al, 2013;Chettier et al, 2014;Szatkiewicz et al, 2014;Furuya et al, 2015].…”
supporting
confidence: 59%
“…Genomic and molecular-phenotypic heterogeneity due to CNV is thought to influence HCC development and progression. 7 Many examples of CNV have been identified in intergenic regions of DNA in human HCC cells. 19,20,25 In this study, based on WGS and bioinformatics analyses of 49 matched HCC samples and para-cancer tissues, the genomic CNV of lncRNAs in Chinese patients with early HCC recurrence after curative resection was revealed for the first time.…”
Section: Discussionmentioning
confidence: 99%
“…CNV plays critical roles in cancer development and progression by activating oncogenes and inactivating tumor suppressors. 7 Protein-coding genes only account for 2% of the human genome, and numerous CNVs in noncoding genomic regions appear at a high frequency in populations. 8 Long noncoding RNAs (lncRNAs) are transcribed RNA sequences at least 200 nucleotides in length that do not encode any protein.…”
Section: Introductionmentioning
confidence: 99%
“…Genomic and molecular phenotype heterogeneity due to CNV is thought to in uence HCC development and progression [21]. Many CNVs have been identi ed in intergenic regions of DNA in human HCC cells [22].…”
Section: Discussionmentioning
confidence: 99%