Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice

Sameni, Hamid Reza; Yosefi, Sedighe; Alipour, M J Gol; Pakdel, Abbas; Torabizadeh, Najmeh; Semnani, Vahid; Bandegi, Ahmad Reza

doi:10.1016/j.lfs.2021.119390

“…Sameni and colleagues showed in a mouse model of colorectal cancer that administration of Iranian propolis extract in combination with 5-fluorouracil (5-FU) significantly reduced the number of azaxymethane-induced aberrant crypt foci compared to 5-FU or propolis alone. Moreover, the propolis combined with 5-FU decreased the expression of Cox-2, iNOS, and β-catenin proteins, which play an important role in the incidences and progression of colorectal cancer [ 135 ].…”

Section: The Use Of Propolis and Its Components In Cancer Therapymentioning

confidence: 99%

Anticancer Activity of Propolis and Its Compounds

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2021

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Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer is one of the major burdens of disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents and treatments for cancer. Propolis is a rich source of biologically active compounds, which affect numerous signaling pathways regulating crucial cellular processes. The results of the latest research show that propolis can inhibit proliferation, angiogenesis, and metastasis of cancer cells and stimulate apoptosis. Moreover, it may influence the tumor microenvironment and multidrug resistance of cancers. This review briefly summarizes the molecular mechanisms of anticancer activity of propolis and its compounds and highlights the potential benefits of propolis to reduce the side effects of chemotherapy and radiotherapy.

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“…Propolis is a resin produced by bees from various plants with different properties, such as anticancer, anti-in ammatory, antibacterial, and anti-oxidant, with no known serious side effects. This natural agent mainly exerts its effects by inhibiting mitochondrial stress, cell proliferation, and growth, stimulating cell cycle arrest, and inducing apoptosis (42).…”

Section: Discussionmentioning

confidence: 99%

The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats

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Hosseinzadeh

²

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Liang

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et al. 2022

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Background 5- Fluorouracil (5-FU) is one of the most common chemotherapeutic agents used in treating solid tumors, and the 5-FU-induced cardiotoxicity is the second cause of cardiotoxicity induced by chemotherapeutic drugs. Propolis (Pro) has vigorous anti-inflammatory activity. Its cardio-protective characteristic against doxorubicin-induced cardiotoxicity was previously proven. The current study aimed to appraise the effect of Pro on 5-FU-induced cardiotoxicity in rats. Methods Twenty-four male Wistar rats were divided into four groups: Control, 5-FU, 5-FU + Pro 250 mg/kg, and 5-FU + Colchicine (CLC) 5 mg/kg. Different hematological, serological, biochemical, histopathological, and molecular assays were performed to assess the study aim. Moreover, rat myocardium (H9C2(2 − 1)) and human skin fibroblast (HNFF-P18) cell lines were also used to assess this protective effect in-vitro. Results 5-FU resulted in significant cardiotoxicity represented by an increase in malondialdehyde (MDA) levels, cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) expression, cardiac enzyme levels, and histopathological degenerations. 5-FU treatment also decreased bodyweight, total anti-oxidant capacity (TAC), catalase (CAT) levels, blood cell counts, and hemoglobin (Hb) levels. In addition, 5-FU disrupted ECG parameters, including increased elevation in the ST-segment and increased QRS complex and QTc duration. Treating with Pro reduced oxidative stress, cardiac enzymes, histopathological degenerations, and COX-2 expression in cardiac tissue alleviated ECG disturbances and increased the number of blood cells and TAC levels. Moreover, 5-FU-induced bodyweight loss was ameliorated after treatment with Pro. Conclusion Our results demonstrated that treatment with Pro significantly improved cardiotoxicity induced by 5-FU in rats.

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“…A systematic review demonstrated that following propolis use, serum levels of TNF-α and CRP were signi cantly reduced 60 . Moreover, consumption of 5-FU signi cantly upregulated COX-2 expression, but simultaneous treatment with propolis counterbalanced and downregulated its expression in a dosedependent manner 42 .…”

Section: Discussionmentioning

confidence: 99%

The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats

Barary

¹

,

Hosseinzadeh

²

,

Liang

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Background 5- Fluorouracil (5-FU) is one of the most common chemotherapeutic agents used in treating solid tumors, and the 5-FU-induced cardiotoxicity is the second cause of cardiotoxicity induced by chemotherapeutic drugs. Propolis (Pro) has vigorous anti-inflammatory activity. Its cardio-protective characteristic against doxorubicin-induced cardiotoxicity was previously proven. The current study aimed to appraise the effect of Pro on 5-FU-induced cardiotoxicity in rats. Methods Twenty-four male Wistar rats were divided into four groups: Control, 5-FU, 5-FU + Pro 250 mg/kg, and 5-FU + Colchicine (CLC) 5 mg/kg. Different hematological, serological, biochemical, histopathological, and molecular assays were performed to assess the study aim. Moreover, rat myocardium (H9C2(2 − 1)) and human skin fibroblast (HNFF-P18) cell lines were also used to assess this protective effect in-vitro. Results 5-FU resulted in significant cardiotoxicity represented by an increase in malondialdehyde (MDA) levels, cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) expression, cardiac enzyme levels, and histopathological degenerations. 5-FU treatment also decreased bodyweight, total anti-oxidant capacity (TAC), catalase (CAT) levels, blood cell counts, and hemoglobin (Hb) levels. In addition, 5-FU disrupted ECG parameters, including increased elevation in the ST-segment and increased QRS complex and QTc duration. Treating with Pro reduced oxidative stress, cardiac enzymes, histopathological degenerations, and COX-2 expression in cardiac tissue alleviated ECG disturbances and increased the number of blood cells and TAC levels. Moreover, 5-FU-induced bodyweight loss was ameliorated after treatment with Pro. Conclusion Our results demonstrated that treatment with Pro significantly improved cardiotoxicity induced by 5-FU in rats.

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Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice

Cited by 26 publications

References 46 publications

Anticancer Activity of Propolis and Its Compounds

Anticancer Activity of Propolis and Its Compounds

The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats

The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats

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