Co-administration of a probiotic strain Lactobacillus plantarum LS/07 CCM7766 with prebiotic inulin alleviates the intestinal inflammation in rats exposed to N,N-dimethylhydrazine

Štofilová, Jana; Szabadosová, Viktória; Hrčková, Gabriela; Salaj, Rastislav; Bertková, Izabela; Hijová, Emília; Strojný, Ladislav; Bomba, Alojz

doi:10.1016/j.intimp.2014.12.022

Cited by 31 publications

(21 citation statements)

References 42 publications

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“…N,N -dimethylhydrazine administration triggered the production of IL-2, IL-6, IL-17, and TNF-α, as well as the expression of NF-κB, COX-2, and iNOS, and caused the depletion of goblet cells. L. plantarum LS/07 CCM7766 alone and in combination with inulin abolished the inflammatory process in the jejunal mucosa by inhibiting the production of pro-inflammatory cytokines and stimulating IL-10 cytokine synthesis, whereas the TGF-β1 levels did not change significantly [59]. …”

Section: Resultsmentioning

confidence: 99%

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

et al. 2017

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Probiotics and synbiotics are used to treat chronic diseases, principally due to their role in immune system modulation and the anti-inflammatory response. The present study reviewed the effects of probiotics and synbiotics on intestinal chronic diseases in in vitro, animal, and human studies, particularly in randomized clinical trials. The selected probiotics exhibit in vitro anti-inflammatory properties. Probiotic strains and cell-free supernatants reduced the expression of pro-inflammatory cytokines via action that is principally mediated by toll-like receptors. Probiotic administration improved the clinical symptoms, histological alterations, and mucus production in most of the evaluated animal studies, but some results suggest that caution should be taken when administering these agents in the relapse stages of IBD. In addition, no effects on chronic enteropathies were reported. Probiotic supplementation appears to be potentially well tolerated, effective, and safe in patients with IBD, in both CD and UC. Indeed, probiotics such as Bifidobacterium longum 536 improved the clinical symptoms in patients with mild to moderate active UC. Although it has been proposed that probiotics can provide benefits in certain conditions, the risks and benefits should be carefully assessed before initiating any therapy in patients with IBD. For this reason, further studies are required to understand the precise mechanism by which probiotics and synbiotics affect these diseases.

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Section: Resultsmentioning

confidence: 99%

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

et al. 2017

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“…The microbiota-gut-brain axis (MGB) theory has been previously proposed and provided evidence regarding the connection between ADHD and maternal inflammation (69). Previous studies have determined that gut microbes are associated with the body's immune system and that gut microbes aid in the maintenance of homeostasis and ensure the normal operation of the immune system by mutual exchange of cytokines with the intestinal epithelium and intestinal mucosal cells (70,71). The gut microbiota may also pass through the BBB and influence the CNS immune system (72).…”

Section: Hypothesis: Adhd May Be a Highly Inflammation And Immune-relmentioning

confidence: 99%

Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease

Zhou

Wang

Sun

et al. 2017

Molecular Medicine Reports

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Attention deficit hyperactivity disorder (ADHD) is a common behavioral disorder. Previous research has indicated that genetic factors, family education, environment and dietary habits are associated with ADHD. It has been determined that in China many children with ADHD also have allergic rhinitis or asthma. These children are more susceptible to the common cold or upper respiratory infections compared with normal healthy children. Additionally, the common cold or an upper respiratory infection may lead to disease recurrence or worsen the symptoms in these children. Previous studies have determined that ADHD may have a close association with allergic disease. Based on the clinically observed phenomenon and previous studies, it was hypothesized that ADHD is a high inflammation and immune‑associated disease. Therefore, the authors designed clinical and animal experiments to test this hypothesis in the future. Immune system disorders may be a novel part of the etiology of ADHD. The current report may have implications for future clinical practice.

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“…NF‐κB is a central transcription factor in allergic inflammatory diseases and in chronic intestinal inflammation because it regulates numerous proinflammatory genes, including cytokines, chemokines, and adhesion molecules (Jobin & Sartor, ). Štofilová et al () reported that the number of NF‐κB positive cells was significantly increased in intestinal inflammation. The expression of inflammatory cytokines in activated human mast cells is also positively correlated with enhanced NF‐κB expression (Han et al, ; Nam et al, ; Song et al, ) and increased NF‐κB activity has been identified in various inflammatory disorders (Choi, Kim, Ko, & Lee, ; Miagkov et al, ; Poynter, Irvin, & Janssen‐Heininger, ).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory efficacy of Beauty-salt is mediated by the caspase-1/NF-κB/RIP2/MAP kinase pathway in mast cells

et al. 2017

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Beauty‐salt (BS, Mi‐salt) is a type of food additive mainly used in Korea. It is composed of solar salt and Impatiens balsamina L. extracts. Here, the present study reports the immunomodulatory efficacy and underlying mechanisms of BS and its active components, ferulic acid (FA) and magnesium (Mg), on the human mast cell line HMC‐1. BS significantly suppressed the production and mRNA expression of the proinflammatory cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)‐1β, IL‐6, and IL‐8 in activated HMC‐1 cells without cytotoxicity. FA or Mg significantly decreased the production of TSLP and IL‐1β but not IL‐6 and IL‐8. In activated mast cells, the pathways of caspase‐1, nuclear factor (NF)‐κB, and receptor‐interacting protein 2 (RIP2) were blocked by treatment with BS, FA, or Mg. Furthermore, BS suppressed the activation of mitogen‐activated protein (MAP) kinases. The present findings provide new scientific evidence that BS has good immunomodulatory efficacy by down‐regulating caspase‐1/NF‐κB/RIP2/MAP kinase pathways. Practical applications Beauty‐salt (BS, Mi‐salt) is a type of food additive mainly used in Korea. BS inhibited the production of proinflammatory cytokines via the blockade of caspase‐1, NF‐κB, and MAPK pathways. Therefore, these results suggest that BS has immunomodulatory efficacy that can play a beneficial role in strategies to prevent and treat inflammatory disorders.

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Co-administration of a probiotic strain Lactobacillus plantarum LS/07 CCM7766 with prebiotic inulin alleviates the intestinal inflammation in rats exposed to N,N-dimethylhydrazine

Cited by 31 publications

References 42 publications

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease

Immunomodulatory efficacy of Beauty-salt is mediated by the caspase-1/NF-κB/RIP2/MAP kinase pathway in mast cells

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