Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model

Yousefi, Bahman; Semnani, Vahid; Mokhtari, Tahmineh; Zarbakhsh, Sam; Amjad, Mohammad Hasan Tabrizi; Barati, Mehdi; Doustmohammadi, Hoda

doi:10.1007/s12011-020-02200-0

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…They had a significant difference compared to the control group. In women-related diseases, including uterine fibroids [35], chronic vaginitis, and ovarian toxicity, propolis has been used for treatment [36]. Also, it has been shown that the administration of aluminum sulfate and propolis has been a successful treatment to improve uterine leiomyoma [35].…”

Section: Discussionmentioning

confidence: 99%

“…In women-related diseases, including uterine fibroids [35], chronic vaginitis, and ovarian toxicity, propolis has been used for treatment [36]. Also, it has been shown that the administration of aluminum sulfate and propolis has been a successful treatment to improve uterine leiomyoma [35]. Ali et al (2018) used a randomized controlled clinical trial to demonstrate the beneficial effects of propolis on uterine leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

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Comparing the Effects of Consuming Propolis and Chicory for Eight Weeks and Resistance Training on Histopathological and Morphometric Changes of Uterine Tissue in Rats Treated With Testosterone Enanthate

Movahed¹,

Beni²,

Cheraghi³

2022

PBR

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Background: The illegal use of anabolic and androgenic steroids is a public health problem and their side effects in women are different from the side effects observed in men. Objectives: This study aims to compare the effects of consuming propolis and chicory for 8 weeks and resistance training on histopathological and morphometric changes of the uterine tissue in rats treated with testosterone enanthate. Methods: In this experimental study, 40 female Wistar rats were randomly divided into 5 groups (n=8): control (placebo), sham (resistance training), resistance training plus testosterone enanthate (20 mg/kg body weight), resistance training plus testosterone enanthate+chicory (6 g/kg body weight), and resistance training plus testosterone enanthate plus propolis (400 mg/kg body weight). The resistance training protocol was performed 5 sessions per week in 4 rounds with an intensity of 40% to 160% of the body weight of the mice for 8 weeks. After weighing and dissection, the uterine tissue was examined histologically. Results: The thickness of the endometrial layer in the sham, testosterone, and propolis groups showed a significant decrease compared to the control group (P<0.05). There was a significant decrease in the thickness of the functional layer in the sham, testosterone, chicory, and propolis groups compared to the control group (P<0.05). The thickness of the basal layer showed a significant decrease in the testosterone and propolis groups compared to the control group (P<0.05). Glands in the testosterone, chicory, and propolis groups showed a significant decrease compared to the control group (P<0.05). The thickness of the myometrial layer showed a significant decrease in the testosterone group compared to the control, sham, chicory, and propolis groups (P<0.05). Conclusion: The results showed that high-intensity resistance training combined with the use of testosterone enanthate causes histopathological changes in the uterus of female rats. Meanwhile, the use of propolis and chicory can improve the effects of testosterone enanthate as a treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparing the Effects of Consuming Propolis and Chicory for Eight Weeks and Resistance Training on Histopathological and Morphometric Changes of Uterine Tissue in Rats Treated With Testosterone Enanthate

Movahed¹,

Beni²,

Cheraghi³

2022

PBR

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Animal models of uterine leiomyomas: a review

et al. 2022

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Mineral medicine: from traditional drugs to multifunctional delivery systems

Zhong

et al. 2022

Chin Med

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Mineral drugs are an important constituent of traditional Chinese medicine (TCM). Taking minerals that contain heavy metals as drugs is a very national characteristic part of TCM. However, the safety and scientific nature of mineral drugs are controversial owing to their heavy metals and strong toxicity. In 2000, the Food and Drug Administration (FDA) authorized arsenic trioxide (ATO) as first-line therapy for acute promyelocytic leukemia. This makes the development and utilization of mineral drugs become a research hotspot. The development of nanomedicine has found a great prospect of mineral drugs in nano-delivery carriers. And that will hold promise to address the numerous biological barriers facing mineral drug formulations. However, the studies on mineral drugs in the delivery system are few at present. There is also a lack of a detailed description of mineral drug delivery systems. In this review, the advanced strategies of mineral drug delivery systems in tumor therapy are summarized. In addition, the therapeutic advantages and research progress of novel mineral drug delivery systems are also discussed. Here, we hope that this will provide a useful reference for the design and application of new mineral drug delivery systems. Graphical Abstract

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Co-administration of Aluminum Sulfate and Propolis Regulates Matrix Metalloproteinases-2/9 Expression and Improves the Uterine Leiomyoma in Adult Rat Model

Cited by 3 publications

References 62 publications

Comparing the Effects of Consuming Propolis and Chicory for Eight Weeks and Resistance Training on Histopathological and Morphometric Changes of Uterine Tissue in Rats Treated With Testosterone Enanthate

Comparing the Effects of Consuming Propolis and Chicory for Eight Weeks and Resistance Training on Histopathological and Morphometric Changes of Uterine Tissue in Rats Treated With Testosterone Enanthate

Animal models of uterine leiomyomas: a review

Mineral medicine: from traditional drugs to multifunctional delivery systems

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