2005
DOI: 10.1159/000084571
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Co-Administration of Cyclosporine and Ketoconazole in Children with Minimal Change Nephrotic Syndrome

Abstract: Background/Aims: The use of cyclosporine A (CsA) in the treatment of idiopathic nephrotic syndrome was firstly reported in 1986. On the other hand, many studies have documented the benefit of ketoconazole (keto) administration in renal and cardiac transplant adults treated with CsA, but this co-administration has not been reported in children with minimal change disease (MCD). Thus, deliberate use of keto to reduce the need for cyclosporine is not new, but it is particularly relevant because of the high cost o… Show more

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