Co-administration of tissue plasminogen activator and hyperbaric oxygen in ischemic stroke: a continued promise for neuroprotection

Yang, Zesong; Mu, Jun

doi:10.4103/2045-9912.202912

Cited by 11 publications

(7 citation statements)

References 67 publications

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“…Therefore, sufficient oxygen in the air is very important for the normal growth and development of animals. Experimental studies found that O 2 supplementation has some beneficial effects including neuroprotective 35 , ischemic tissue 36 , angiogenesis and wound healing 12 , 13 . However, whether O 2 supplementation has a promoting effect on the growth of TBCs or ameliorating effect on hypoxia-suppressed weight gain is unclear.…”

Section: Discussionmentioning

confidence: 99%

Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes

Huang¹,

Tong²,

Rehman³

et al. 2017

Int. J. Biol. Sci.

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Tibetan chickens (TBCs) living in high-altitude hypoxic environment, are characterized by delayed growth and small size as compared to low-altitude broiler chickens. Increasing evidences signify the beneficial effect of oxygen (O2) supplementation in animal's body for regulating their body growth and organ development. However, it is still unclear that whether O2 supplementation has an ameliorative and protective role in TBCs living at high altitude. In this study, we first found that O2 supplementation not only increased the survival rate but also promoted the growth of TBCs associated with bone development. Importantly, we observed that the increase of vascular distribution in the tibial hypertrophic zone could contribute to promote growth and development of the tibia, which is highly correlated with the up-regulated expression level of vascular endothelial growth factor (VEGF)-A and VEGF receptor-1 (VEGFR1). Additionally, hypoxia inducible factor (HIF)-1ɑ also has a stimulative elevation by O2 supplementation. These results were confirmed by histology, immunohistochemistry, qRT-PCR and Western blotting techniques. Altogether, these findings demonstrated that the up-regulation of VEGFA and its receptors are accompanied by proangiogeneic factor (HIF-1α) expression, which were required for angiogenesis to meliorate tibia development of TBCs in hypoxia-induced bone suppression that occurred during O2 supplementation. Thus, O2 supplementation may serve as a good applicant for promoting and meliorating bone development in juvenile high-altitude animals.

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Section: Discussionmentioning

confidence: 99%

Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes

Huang¹,

Tong²,

Rehman³

et al. 2017

Int. J. Biol. Sci.

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“…Although hyperbaric oxygenation (HBO) therapy is not recommended by American Heart Association and Stroke Association guidelines (Jauch et al, 2013; Misir et al, 2017), HBO therapy is a widely used non-pharmacologic and non-invasive clinical treatment of ischemic stroke (Hu et al, 2014; Yang and Mu, 2017). It enhances oxygen supply, stabilizes the BBB, and decreases infarct size and cerebral edema in global or focal ischemia stroke (Neumann-Haefelin et al, 2000; Veltkamp et al, 2005).…”

Section: Recently Identified Therapeutic Aims and Therapiesmentioning

confidence: 99%

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

Shekhar

Cunningham

Pabbidi

et al. 2018

European Journal of Pharmacology

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Ischemic stroke is a devastating and debilitating medical condition with limited therapeutic options. However, accumulating evidence indicates a central role of inflammation in all aspects of stroke including its initiation, the progression of injury, and recovery or wound healing. A central target of inflammation is disruption of the blood brain barrier or neurovascular unit. Here we discuss recent developments in identifying potential molecular targets and immunomodulatory approaches to preserve or protect barrier function and limit infarct damage and functional impairment. These include blocking harmful inflammatory signaling in endothelial cells, microglia/macrophages, or Th17/γδ T cells with biologics, third generation epoxyeicosatrienoic acid (EET) analogs with extended half-life, and miRNA antagomirs. Complementary beneficial pathways may be enhanced by miRNA mimetics or hyperbaric oxygenation. These immunomodulatory approaches could be used to greatly expand the therapeutic window for thrombolytic treatment with tissue plasminogen activator (t-PA). Moreover, nanoparticle technology allows for the selective targeting of endothelial cells for delivery of DNA/RNA oligonucleotides and neuroprotective drugs. In addition, although likely detrimental to the progression of ischemic stroke by inducing inflammation, oxidative stress, and neuronal cell death, 20-HETE may also reduce susceptibility of onset of ischemic stroke by maintaining autoregulation of cerebral blood flow. Although the interaction between inflammation and stroke is multifaceted, a better understanding of the mechanisms behind the pro-inflammatory state at all stages will hopefully help in developing novel immunomodulatory approaches to improve mortality and functional outcome of those inflicted with ischemic stroke.

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“…Lack of blood supply deprives the brain cells of necessary glucose and oxygen, and disturbs cellular homeostasis, culminating in neuronal death. Currently, tissue plasminogen activator (tPA) is the only effective pharmacological therapy approved by the Food and Drug Administration for acute ischemic stroke since 1996, but its use remains limited due to the narrow therapeutic window [ 3 - 6 ]. It is imperative to develop novel therapeutic strategies of stroke [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Mitochondria in Ischemic Stroke: New Insight and Implications

et al. 2018

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Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.

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Co-administration of tissue plasminogen activator and hyperbaric oxygen in ischemic stroke: a continued promise for neuroprotection

Cited by 11 publications

References 67 publications

Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes

Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes

Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches

Mitochondria in Ischemic Stroke: New Insight and Implications

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