Co-administration of walnut (
            <i>Juglans regia</i>
            ) prevents systemic hypertension induced by long-term use of dexamethasone: a promising strategy for steroid consumers

Joukar, Siyavash; Ebrahimi, Sahar; Khazaei, Majid; Bashiri, Alireza; Shakibi, Mohammad Reza; Naderi, Vida; Shahouzehi, Beydolah; Alasvand, Masoud

doi:10.1080/13880209.2016.1233570

Cited by 16 publications

(12 citation statements)

References 37 publications

(36 reference statements)

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“…Dexamethasone (DEX)‐induced hypertension has been shown by our group and others in both animals (Constantino et al, 2017; Dodic et al, 1999; Herrera et al, 2017; Herrera, Duchatsch, Tardelli, Dionisio, Santos, et al, 2020; Jesus et al, 2020; Joukar et al, 2017; Mondo et al, 2006; Ong et al, 2013) and humans (Anwar et al, 2016; Brotman et al, 2005; Williamson et al, 2015), but the effects of DEX on arterial stiffness are still unclear. This secondary type of hypertension has been associated with increased sympathetic nerve activity and impaired baroreflex activity (Constantino et al, 2017; Duchatsch et al, 2018; Fletcher et al, 2003; Herrera et al, 2016; Segar et al, 2006), oxidative stress (Joukar et al, 2017; Mondo et al, 2006; Schafer et al, 2005), increased renin angiotensin system activity (Forhead et al, 2000; Forhead et al, 2015; Hoshino et al, 1994; Suzuki et al, 1982) and skeletal muscle rarefaction (Herrera et al, 2016; Herrera et al, 2017; Herrera, Duchatsch, Tardelli, Dionisio, Shinohara, et al, 2020; Jesus et al, 2020). Preliminary results from our laboratory (data not published) have suggested that DEX‐induced hypertension was associated arterial stiffness, but the mechanisms are not totally clear.…”

Section: Introductionmentioning

confidence: 76%

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Tardelli

Duchatsch

Herrera

et al. 2021

J of Applied Toxicology

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Dexamethasone (DEX)‐induced hypertension is observed in normotensive rats, but little is known about the effects of DEX on spontaneously hypertensive animals (SHR). This study aimed to evaluate the effects of DEX on hemodynamics, cardiac hypertrophy and arterial stiffness in normotensive and hypertensive rats. Wistar rats and SHR were treated with DEX (50 μg/kg s.c., 14 d) or saline. Pulse wave velocity (PWV), echocardiographic parameters, blood pressure (BP), autonomic modulation and histological analyses of heart and thoracic aorta were performed. SHR had higher BP compared with Wistar, associated with autonomic unbalance to the heart. Echocardiographic changes in SHR (vs. Wistar) were suggestive of cardiac remodeling: higher relative wall thickness (RWT, +28%) and left ventricle mass index (LVMI, +26%) and lower left ventricle systolic diameter (LVSD, −19%) and LV diastolic diameter (LVDD, −10%), with slightly systolic dysfunction and preserved diastolic dysfunction. Also, SHR had lower myocardial capillary density and similar collagen deposition area. PWV was higher in SHR due to higher aortic collagen deposition. DEX‐treated Wistar rats presented higher BP (~23%) and autonomic unbalance. DEX did not change cardiac structure in Wistar, but PWV (+21%) and aortic collagen deposition area (+21%) were higher compared with control. On the other side, DEX did not change BP or autonomic balance to the heart in SHR, but reduced RWT and LV collagen deposition area (−12% vs. SHRCT). In conclusion, the results suggest a differential effect of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats.

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Section: Introductionmentioning

confidence: 76%

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Tardelli

Duchatsch

Herrera

et al. 2021

J of Applied Toxicology

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“…Two-way ANOVA followed with post-hoc test did not confirm any significant effect of walnut diet on eNOS expression, in contrast to our expectations. Namely, walnuts contain considerable amounts of L-arginine, which is the precursor amino acid for NO biosynthesis (Xiao et al 2018) and improves serum NO level (Joukar et al 2017). The effects of LA and ALA, highly represented in walnut kernel, on endothelial cell functions and the related gene expression are influenced by LA/ALA ratios and their concentrations, and the mechanism may be partially mediated through NO/eNOS signalling pathways (Yang et al 2018).…”

Section: Protein Kinasesmentioning

confidence: 99%

Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

Stanišić

Ivković

Romić

et al. 2020

International Journal of Food Sciences and Nutrition

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Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.

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“…In this context, some species of the Juglans genus exhibit diverse biological activities that may be helpful in the treatment of diseases such as diarrhea, helminthiasis, sinusitis, arthritis, stomach pain, fever, eczema, diabetes mellitus, skin disorders, asthma, hepatitis, liver fibrosis, dysfunctional thyroid, anorexia, urinary tract infection, and cancer [9–13]. The Juglans genus has been reported to have antihypertensive activity [14–17] as well as antioxidant, lipolytic [18], antihyperglycemic, antilipidemic [19], neuronal cell-stimulating [20], and antiproliferative properties [21].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia–reperfusion damage in a Wistar rat model

Pérez-Meseguer

Torres-González

Gutiérrez-González

et al. 2019

BMC Complement Altern Med

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Background Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We evaluated whether a methanolic extract of Juglans mollis (JM) exhibits nephroprotective activity in a Wistar rat model of I/R injury. Methods Four groups of six rats were used: Sham, I/R, JM, and JM + I/R. Two groups were dosed with JM (300 mg/kg) for 7 days before I/R. I/R injury was induced by clamping the renal hilums for 45 min and then reperfusing the kidneys for 15 h. Blood samples were taken to evaluate the levels of alanine aminotransferase (ALT), blood urea nitrogen, creatinine, superoxide dismutase (SOD), malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α). Results The levels of creatinine, ALT, MDA, IL-1β, IL-6, and TNF-α were lower in JM + I/R than in I/R rats, whereas SOD level only was higher in JM + I/R than in Sham rats. No biochemical or histological damage was observed in JM rats compared with Sham rats; however, less histological damage was observed in JM + I/R rats compared with I/R rats. Conclusions To our knowledge, this is the first report of nephroprotective activity of J. mollis against damage induced by I/R. This activity may be related to decreased levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α) and modulation of oxidative stress markers (SOD and MDA) observed in the present study.

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Co-administration of walnut ( Juglans regia ) prevents systemic hypertension induced by long-term use of dexamethasone: a promising strategy for steroid consumers

Abstract: Similar to captopril, walnut extract normalized dexamethasone-induced hypertension. A part of this beneficial effect apparently involves maintaining balance of the redox system and NO production.

Cited by 16 publications

References 37 publications

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Differential effects of dexamethasone on arterial stiffness, myocardial remodeling and blood pressure between normotensive and spontaneously hypertensive rats

Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

Anti-inflammatory and nephroprotective activity of Juglans mollis against renal ischemia–reperfusion damage in a Wistar rat model

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