Co-assembled supramolecular hydrogels of cell adhesive peptide and alginate for rapid hemostasis and efficacious wound healing

Zhai, Ziran; Xu, Keming; Mei, Leixia; Wu, Can; Liu, Jing; Liu, Ziqi; Wan, Lanxin; Zhong, Wenying

doi:10.1039/c9sm01296f

Cited by 77 publications

(67 citation statements)

References 40 publications

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“…Rong et al (2015) prepared a thrombin-loaded alginate calcium microsphere via the emulsion crosslinking technique, which can transport the hemostatic agent for the blunt injury and abdominal solid viscera bleeding. Zhai et al (2019) demonstrated a co-assembly system of peptide binding compound and alginatewith attractive cell adhesions, which exhibited the effective hemostatic property without adding other growth factors (Figure 9). This composite hydrogel can quickly stop bleeding after adding whole blood in vitro, and reduce the bleeding volume of the mouse liver puncture model to about 18% of the untreated group.…”

Section: Alginatementioning

confidence: 99%

“…This composite hydrogel can quickly stop bleeding after adding whole blood in vitro, and reduce the bleeding volume of the mouse liver puncture model to about 18% of the untreated group. Meanwhile, it promoted the migration of fibroblasts and accelerates wound healing speed of the mouse full-thickness skin defect model, which was developed into the promising nanocomposite materials for a variety of biomedical applications (Zhai et al, 2019). Huang et al (2019) prepared a hemostatic composite (SACC) microsphere via the crosslinked technology of sodium alginate (SA), carboxymethyl chitosan (CMC) and collagen.…”

Section: Alginatementioning

confidence: 99%

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Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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Rapid hemostasis and formation of stable blood clots are very important to prevent massive blood loss from the excessive bleeding for living body, but their own clotting process cannot be completed in time for effective hemostasis without the help of hemostatic materials. In general, traditionally suturing and stapling techniques for wound closure are prone to cause the additional damages to the tissues, activated inflammatory responses, short usage periods and inevitable second operations in clinical applications. Especially for the large wounds that require the urgent closure of fluids or gases, these conventional closure methods are far from enough. To address these problems, various tissue adhesives, sealants and hemostatic materials are placed great expectation. In this review, we focused on the development of two main categories of tissue adhesive materials: synthetic polymeric adhesives and naturally derived polysaccharide adhesives. Research of the high performance of hemostatic adhesives with strong adhesion, better biocompatibility, easy usability and cheap price is highly demanded for both scientists and clinicians, and this review is also intended to provide a comprehensive summarization and inspiration for pursuit of more advanced hemostatic adhesives for biological fields.

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Section: Alginatementioning

confidence: 99%

Section: Alginatementioning

confidence: 99%

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Front. Bioeng. Biotechnol.

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“…Compared to the Pept-1 gel alone, the electrostatic interaction and metal chelation-mediated assembly method afforded the composite hydrogel with better mechanical strength and denser nanofibril structure. The Pept-1/ALG hydrogel presented with excellent injectability, thixotropy, and biocompatibility, promoting adhesion and migration of fibroblast cells in vitro ( Zhai et al, 2019 ). ECM not only provides abundant biologically active molecules for cell proliferation, migration and differentiation, but also affects cell behavior and function through the intertwined collagen fibers.…”

Section: Supramolecular Hydrogels For Stem Cell Deliverymentioning

confidence: 99%

Advances in the Application of Supramolecular Hydrogels for Stem Cell Delivery and Cartilage Tissue Engineering

Yan

Chen

Song

et al. 2020

Front. Bioeng. Biotechnol.

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Cartilage defects pose a great threat to the health of the aging population. Cartilage has limited self-regeneration ability because it lacks blood vessels, nerves and lymph. To achieve efficient cartilage regeneration, supramolecular hydrogels are used in medical applications and tissue engineering as they are tunable and reversible in nature. Moreover, they possess supramolecular interactions which allow the incorporation of cells. These hydrogels present great potential for tissue engineering-based therapies. This review presents advances in the development of stem cell-laden supramolecular hydrogels. We discuss new possibilities for stem cell therapy and their uses in cartilage tissue engineering. Gray areas and future perspectives are discussed.

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“…Along the same line, Zhai et al reported the ionic coassembly of alginate and a cell adhesive peptide conjugate. [213] The resultant supramolecular hydrogels with denser nanofibrillar structures exhibited excellent mechanical properties and biocompatibility. The authors demonstrated that the coassembling process was mediated by electrostatic interactions and metal chelation.…”

Section: Cationic Peptides and Other Anionic Polymersmentioning

confidence: 99%

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

Xie

Zheng

2020

Macromol. Rapid Commun.

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innovative insight into understanding the properties of the material systems beyond molecular level. [6-8] Through the last decades, supramolecular chemistry has deeply permeated and fused with biology and materials science, and has gradually growth into an interdisciplinary platform for the creation of self-assembled systems with extraordinary properties. [9-12] Among the numerous systems, self-assembled peptide is one of the most important branches, because of its rich chemical diversity, versatile characters, inherent biocompatibility, and bioactivity. [13-15] Specifically, the natural or chemically engineered amino acids encoded in the sequence of peptide molecules enable the formation of customizable secondary structures, the cooperative interactions between main chains and side chains of peptide molecules can be further leveraged to produce hierarchical nanostructures [16-22] and important biofunctions, such as drug delivery, [23-25] tissue engineering, [26-28] regenerative medicine, [29-31] and biomineralization. [32-35] Moreover, many studies have disclosed that self-assembled peptide nanostructures can offer higher performance (catalytic, therapeutic, targeting, etc.) than peptide itself. [36-42] For those reasons, peptide self-assembly has been recognized as a subject of great importance in supramolecular chemistry, biology, and nanotechnology, and the breadth and depth of peptide selfassemblies have been documented and demonstrated in several excellent reviews. [43-51] Besides the self-assembly of unimolecular peptides, multicomponent coassembly between peptides and other building blocks has recently become increasingly prevalent, as the modular approach offers a simple and effective way to arrive at supramolecular materials with wide structural complexity and value-added properties for multiple tasks applications. [52-56] This integrated characteristic further stimulates researchers to explore the scope of peptide coassembly with the aim of expanding the space of functional utility. To selectively form the multicomponent nanostructures, the interplay of the driving forces should be energetically much more favorable for strengthening the coassembly of distinct components than the self-sorting of the same type of components. [57-59] Following this design criteria, the introduction of complementary noncovalent interactions into the multicomponent systems is Peptide assembly has been extensively exploited as a promising platform for the creation of hierarchical nanostructures and tailor-made bioactive materials. Ionic coassembly of cationic peptides and anionic species is paving the way to provide particularly important contribution to this topic. In this review, the recent progress of ionic coassembly soft materials derived from the electrostatic coupling between cationic peptides and anionic species in aqueous solution is systematically summarized. The presentation of this review starts from a brief background on the general importance and advantages of peptide-based ionic coassembly. After that, divers...

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Co-assembled supramolecular hydrogels of cell adhesive peptide and alginate for rapid hemostasis and efficacious wound healing

Abstract: Co-assembly of a cell adhesive peptide conjugate and alginate affords multifunctional composite hydrogels for rapid hemostasis and efficacious wound healing.

Cited by 77 publications

References 40 publications

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Advances in the Application of Supramolecular Hydrogels for Stem Cell Delivery and Cartilage Tissue Engineering

Recent Progress in Ionic Coassembly of Cationic Peptides and Anionic Species

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