Co-contamination of deltamethrin and cadmium induce oxidative stress in tomato plants (Solanum lycopersicum L.)

Touzout, Nabil; Mehallah, Hafidha; Moralent, Radia; Nemmiche, Saïd; Benkhelifa, Mohammed

doi:10.1007/s11738-021-03261-x

Cited by 12 publications

(2 citation statements)

References 57 publications

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“…Indeed, the carotenoid content was found to decrease under Pb stress in tomato plants, whereas total phenol content was observed to enhance, likely due to a plant adaptation to stress that encourage chelation of toxic metal ions in the aerial parts 39 . A similar response was observed as regards carotenoid content after Cd contamination 40 .…”

Section: Resultssupporting

confidence: 80%

Cytotoxic evaluation and chemical investigation of tomatoes from plants (Solanum lycopersicum L.) grown in uncontaminated and experimentally contaminated soils

Russo

Barone²,

Lavorgna³

et al. 2022

Sci Rep

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The aim of this study was to evaluate the cytotoxic activity and the chemical composition of the tomato extracts coming from, Pomodoro Giallo and San Marzano Cirio 3, and then to evaluate the potential changes when plants were grown in soils contaminated by cadmium, chromium and lead. Extracts were investigated by UHPLC-HRMS and UV–Vis. Cell viability (CellTiter-Glo Luminescent assay), enzyme aldehyde dehydrogenase activity (ALDEFLOUR Assay), cell cycle progression (Accuri C6 Flow Cytometer), apoptosis and necrosis (Annexin V-FITC assay) were evaluated on two gastric cancer (AGS and NCI-N87) and two colorectal cancer (HT-29 and HCT 116) cell lines. Different content of polyphenol and carotenoid constituents was observed. Extracts from uncontaminated soil induced cytotoxic activity towards all selected cancer cells, while extracts coming from contaminated soils showed the aberrant phenotype increased in colorectal cancer cells. Chloroform extracts exerted the highest cytotoxic activity. AGS and HT-29 were the most sensitive to cell cycle arrest and to apoptosis. No necrotic effect was observed in HCT 116. The contrasting effects on cancer cells were observed based on tomato variety, the extract polarity, heavy metal identity, and tested cell line. The investigation of potential adverse health effects due to Cd in the fruits should be explored.

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Section: Resultssupporting

confidence: 80%

Cytotoxic evaluation and chemical investigation of tomatoes from plants (Solanum lycopersicum L.) grown in uncontaminated and experimentally contaminated soils

Russo

Barone²,

Lavorgna³

et al. 2022

Sci Rep

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“…DIF exposure and NaCl stress reduced the chlorophyll content to a great extent. This may be due to the degradation and/or reduction in the formation of photosynthetic pigments caused by the over-accumulation of ROS induced by pollutants (Touzout et al 2021a;Iram et al 2023). A decrease in chlorophyll contents may result in an inhibitory effect on tomato seedlings growth (Tables 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

Breaking New Ground: Uncovering the Synergistic Impact of Difenoconazole and Salt on Tomato (Solanum lycopersicum L) Growth, Photosynthetic Pigments, and Oxidative Stress

Touzout,

Hassani,

Bouzidi

et al. 2023

Preprint

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Studies have shown that exposure to either fungicide difenoconazole (DIF) or salt (NaCl) alone can cause phytotoxicity in plants, but it remains uncertain whether co-exposure to these two xenobiotics, which often co-occur in the agroecosystem, can also induce phytotoxicity. This research aimed to study the phytotoxicity and underlying mechanisms of co-exposure to DIF (field recommended doses (0.5 L ha− 1) and NaCl (150 mM) in tomato seedlings. The results showed that exposure to DIF and/or NaCl causes phytotoxic effects in tomato seedlings, including a decrease in fresh weight and length of shoots and roots, damage to chlorophyll pigment, and induced oxidative stress in the leaves. Interestingly, combined exposure to DIF and NaCl exhibited synergistic effects on shoot and root biomass inhibition. Antioxidant defense analyses revealed that the DIF and/or NaCl exposure altered the activities of enzymes involved in the H2O2 scavenging (ascorbate peroxidase and catalase), and in xenobiotic detoxification (glutathione-s-transferase and peroxidase) in leaf tissues. Interestingly, combined exposure to DIF and NaCl markedly enhanced detoxifying enzymes, thereby enhancing xenobiotic biotransformation. In addition, DIF and/or NaCl exposure enhanced proline accumulation, and altered the thiols profile (reduced glutathione) content, while stimulating the phenylpropanoid pathway (phenylalanine ammonia-lyase activity) to produce secondary metabolites such as polyphenols and flavonoids. As pioneer research to highlight the phytotoxicity induced by co-exposure to DIF and NaCl in tomato seedlings, these results provide new insights into physio-biochemical responses of non-target plants to DIF and NaCl co-contamination and shedding light on the ecological risks of pesticides and salt exposure in agroecosystems.

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Pesticides and Their Effects on Plants: A Case Study of Deltamethrin

Siddiqui

Abbas

Ansari

et al. 2022

Agrochemicals in Soil and Environment

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Co-contamination of deltamethrin and cadmium induce oxidative stress in tomato plants (Solanum lycopersicum L.)

Cited by 12 publications

References 57 publications

Cytotoxic evaluation and chemical investigation of tomatoes from plants (Solanum lycopersicum L.) grown in uncontaminated and experimentally contaminated soils

Cytotoxic evaluation and chemical investigation of tomatoes from plants (Solanum lycopersicum L.) grown in uncontaminated and experimentally contaminated soils

Breaking New Ground: Uncovering the Synergistic Impact of Difenoconazole and Salt on Tomato (Solanum lycopersicum L) Growth, Photosynthetic Pigments, and Oxidative Stress

Pesticides and Their Effects on Plants: A Case Study of Deltamethrin

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