Co-culture of Aspergillus sydowii and Bacillus subtilis induces the production of antibacterial metabolites

Metabolomic profiles of the liquid state fermentation in co-culture of Eurotium amstelodami and Bacillus licheniformis

“…However, the co-culture combination of E. amstelodami and B. amyloliquefaciens achieved an impressive inhibition rate of 90.21%, it seems that the improvement was not significant compared to the pure cultures. Interestingly, the most significant improvement was observed in the co-culture of E. amstelodami and B. licheniformis, indicating that several silenced Sun et al, 2022). In recent years, many research reported that Bacillus species was an ideal strain for establishing co-culture systems, on the one hand, Bacillus species, as a representative of biocontrol microorganisms, the co-culture of Bacillus species and other biocontrol microorganisms exhibited stronger inhibition of plant pathogenic microorganisms and promoted plant growth (Karuppiah et al, 2019;Liu H. et al, 2022), on the other hand, the co-culture of Bacillus species and other microorganisms could markedly increase the production of SMs contained multibiological activity (Sun et al, 2022;Zhang X. F. et al, 2022).…”

“…Interestingly, the most significant improvement was observed in the co-culture of E. amstelodami and B. licheniformis, indicating that several silenced Sun et al, 2022). In recent years, many research reported that Bacillus species was an ideal strain for establishing co-culture systems, on the one hand, Bacillus species, as a representative of biocontrol microorganisms, the co-culture of Bacillus species and other biocontrol microorganisms exhibited stronger inhibition of plant pathogenic microorganisms and promoted plant growth (Karuppiah et al, 2019;Liu H. et al, 2022), on the other hand, the co-culture of Bacillus species and other microorganisms could markedly increase the production of SMs contained multibiological activity (Sun et al, 2022;Zhang X. F. et al, 2022). However, due to the randomness of microbial co-culture as well as the structural complexity of SMs, many potentially promising microbial co-culture combinations remain undiscovered.…”

“… Li T. T. et al (2020) found that the co-culture of Trichoderma atroviride and B. subtilis exhibited improved antifungal activity against Fusarium graminearum , which is the causal agent of Fusarium head blight in many cereal crops. Similarly, the co-culture combination of Aspergillus sydowii and B. subtilis has been shown to significantly increase inhibitory activity against S. aureus ( Sun et al, 2022 ). In recent years, many research reported that Bacillus species was an ideal strain for establishing co-culture systems, on the one hand, Bacillus species, as a representative of biocontrol microorganisms, the co-culture of Bacillus species and other biocontrol microorganisms exhibited stronger inhibition of plant pathogenic microorganisms and promoted plant growth ( Karuppiah et al, 2019 ; Liu H. et al, 2022 ), on the other hand, the co-culture of Bacillus species and other microorganisms could markedly increase the production of SMs contained multibiological activity ( Sun et al, 2022 ; Zhang X. F. et al, 2022 ).…”

“…Here, we propose a strategy to screen co-culture microbial combinations by targeting the improvement of antibacterial activity. Interestingly, studies have shown that changes in state of the medium (i.e., solid or liquid), composition (i.e., carbon source and nitrogen source) and culture conditions (i.e., temperature, culture length, and pH), or the addition of some trace elements might lead to improved antibacterial activity ( Boruta et al, 2020 ; Boruta, 2021 ; Gao et al, 2021 ; Sun et al, 2022 ), which provided new strategies to further explore valuable SMs of the co-culture of E. amstelodami and Bacillus species.…”

Calcium lactate efficiently induces production of bacillomycin D in Bacillus subtilisNS‐174 and inhibition of spore germination of Aspergillus flavus in rice

“…Calcium lactate was an organic salt that could be widely applied in food industry as dietary supplements, fruit preservatives and functional modifiers (Gore et al., 2019; De Maere D'aertrycke et al., 2020; Hu et al., 2022). On the other hand, the metabolomics technology was explored to expound the metabolic regulation pathways (networks) and key differential metabolites resulted by the influencing factors that affected the accumulation of antibacterial metabolites (Sun et al., 2022). However, to date, there has been no publication on how calcium lactate regulates the production of lipopeptides in B. subtilis .…”