Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts

Xu, Jianbin; Zhang, Guolin; Luo, Xin; Wang, Di; Zhou, Wei; Zhang, Yan; Zhang, Wei; Chen, Jiaxin; Meng, Qingguo; Chen, Engeng; Chen, Heng; Song, Zhangfa

doi:10.7150/thno.52076

Cited by 30 publications

(16 citation statements)

References 65 publications

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“…MiR-34a has been identified to have therapeutic potential for cancer. A recent study indicated that co-delivery 5-fluorouracil and miR-34a mimic improved the apoptotic effect and inhibited the metastasis of colorectal cancer cells (96). Further study demonstrated that pre-miR-34a transfection suppressed the expression of target genes, induced apoptosis and decreased the proliferation rate in gastric cancer (97).…”

Section: Anti-mir-34a Therapy In Cvdsmentioning

confidence: 98%

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Hua

Liu

Liang³

et al. 2022

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality worldwide and include a group of disorders varying from vasculature, myocardium, arrhythmias and cardiac development. MicroRNAs (miRs) are endogenous non-coding RNAs with 18–23 nucleotides that regulate gene expression. The miR-34 family, including miR-34a/b/c, plays a vital role in the regulation of myocardial physiology and pathophysiological processes. Recently, miR-34a has been implicated in cardiovascular fibrosis, dysfunction and related cardiovascular disorders as an essential regulator. Interestingly, there is a pivotal link among miR-34a, cardiovascular fibrosis, and Smad4/TGF-β1 signaling. Notably, both loss-of-function and gain-of-function approaches identified the critical roles of miR-34a in cardiovascular apoptosis, autophagy, inflammation, senescence and remodeling by modulating multifunctional signaling pathways. In this article, we focus on the current understanding of miR-34a in biogenesis, its biological effects and its implications for cardiac pathologies including myocardial infarction, heart failure, ischaemia reperfusion injury, cardiomyopathy, atherosclerosis, hypertension and atrial fibrillation. Thus, further understanding of the effects of miR-34a on cardiovascular diseases will aid the development of effective interventions. Targeting for miR-34a has emerged as a potential therapeutic target for cardiovascular dysfunction and related diseases.

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Section: Anti-mir-34a Therapy In Cvdsmentioning

confidence: 98%

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Hua

Liu

Liang³

et al. 2022

Front. Cardiovasc. Med.

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“…Such miRNA mimics can be chemically modified to be more stable or capable of targeted delivery to tumors. miR−34a mimics can be encapsulated into TCP1-CD-QD nanoparticles and transferred into CRC cells, which contributes to the suppression of the proliferation and migration of CRC cells in vitro and inhibition of tumor growth in a tumor xenograft model derived from CRC cells ( 155 ). Moreover, the obtained indicates that co-delivery of miR-34a mimics and 5-FU could achieve synergistic effects for CRC treatment.…”

Section: The Clinical Significance Of Ncrnas In Crcmentioning

confidence: 99%

Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms

Jia

Liu

et al. 2022

Front. Oncol.

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Colorectal cancer (CRC) is a common malignancy with high mortality. However, the molecular mechanisms underlying CRC remain unclear. Controversies over the exact functions of non-coding RNAs (ncRNAs) in the progression of CRC have been prevailing for multiple years. Recently, accumulating evidence has demonstrated the regulatory roles of ncRNAs in various human cancers, including CRC. The intracellular signaling pathways by which ncRNAs act on tumor cells have been explored, and in CRC, various studies have identified numerous dysregulated ncRNAs that serve as oncogenes or tumor suppressors in the process of tumorigenesis through diverse mechanisms. In this review, we have summarized the functions and mechanisms of ncRNAs (mainly lncRNAs, miRNAs, and circRNAs) in the tumorigenesis of CRC. We also discuss the potential applications of ncRNAs as diagnostic and prognostic tools, as well as therapeutic targets in CRC. This review details strategies that trigger the recognition of CRC-related ncRNAs, as well as the methodologies and challenges of studying these molecules, and the forthcoming clinical applications of these findings.

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“…Currently, a number of therapeutic approaches involving miRNAs are being developed: combinations of miRNAs with other agents [ 173 , 174 , 175 , 176 , 177 ], as well as combinations of two miRNAs [ 178 , 179 , 180 ] are being investigated.…”

Section: Prospects For Mirna-based Therapymentioning

confidence: 99%

The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer

Kipkeeva

Музаффарова

Korotaeva

et al. 2022

IJMS

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Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA translation. An important feature of miRNA is its ability to affect the expression of several genes simultaneously, which corresponds to the trend toward the use of combination therapy. The article provides a list of miRNAs acting simultaneously on several ICs and miRNAs that, in addition to IC, can regulate the expression of targeted therapy genes. There is dependence of miRNA interactions with IC genes on the type of cancer. The analysis of the accumulated data demonstrates that only about 14% (95% CI: 9.8–20.1%) of the studied miRNAs regulate the expression of specific IC in more than one type of cancer. That is, there is tumor specificity in the miRNA action on ICs. A number of miRNAs demonstrated high efficiency in vitro and in vivo. This indicates the potential of miRNAs as promising agents for cancer immunotherapy. Additional studies of the miRNA–gene interaction features and the search for an optimal miRNA mimic structure are necessary.

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Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts

Cited by 30 publications

References 65 publications

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms

The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer

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