Co-delivery of all-trans-retinoic acid and docetaxel in drug conjugated polymeric nanoparticles: Improving controlled release and anticancer effect

Karimi, Nadia; Soleiman‐Beigi, Mohammad; Fattahi, Ali

doi:10.1016/j.mtcomm.2020.101280

Cited by 6 publications

(1 citation statement)

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“…The DTX loaded ATRA-g-DBAC nanoparticles show more cytotoxicity and better anti-angiogenic effect compared to free all trans-retinoic acid and docetaxel in chemotherapy. ATRA-g-PBAE nanoparticles are an attractive controlled released system compared to chemotherapy [116].…”

Section: Docetaxel Loaded Polymeric Nanoparticlesmentioning

confidence: 99%

Vitamin Drug conjugate: a systematic review of pharmacological potential

Bhole¹,

Shinde²,

Bonde³

et al. 2021

Bull. of the Kar. Univ. "Chem". Ser.

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Cancer is a chronic disease which can cause death. In traditional chemotherapycytotoxic drugs are used to kill proliferating cancer cells. The cytotoxic agent exhibits less specificity, less biological activity, causes sys-temic toxicity and undesirable side effects. Each year, about 1.8 million of the population are infected and die due to tuberculosis infection. An increase of drug resistance during the tuberculosis treatment is a significant concern. So, it is necessary to develop a new approach or therapies to resolve drug resistance, drug selectivity in tuberculosis infection and the reduction of the side effects of cytotoxic agents and anti-tubercular drugs. This review describes the newly emerging concept of «vitamin drug conjugate». Vitamin-drug conjugate is a specifically carried drug toward the target site, is one of the promising ways to treat chronic diseases like can-cer and tuberculosis and enhance the therapeutic outcome. The purpose of this review is to explore vitamin as a targeting moiety for new anticancer and anti-tubercular drug to overcome challenges, such as non-selectivity, systemic toxicity and multidrug resistance. This approach is beneficial in the treatment of life-threatening disease like cancer, tuberculosis and also in many viral infections.

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Section: Docetaxel Loaded Polymeric Nanoparticlesmentioning

confidence: 99%