Co-delivery of cisplatin and doxorubicin by carboxylic acid functionalized poly (hydroxyethyl methacrylate)/reduced graphene nanocomposite for combination chemotherapy of breast cancer cells

Shahram, Astani; Salehi, Roya; Massoumi, Bakhshali; Massoudi, Abdolhossein

doi:10.1080/09205063.2020.1855393

Cited by 9 publications

(5 citation statements)

References 45 publications

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“…In general, systems that incorporate combination therapies exhibit some of the strongest anticancer effects due to the synergistic effects of PTT, PDT, single-drug and combination chemotherapy, or immunotherapy [ 67 , 129 , 169 , 190 ]. CNMs are the perfect class of nanoparticles for this approach, as they are easy to modify both covalently and noncovalently, with a range of functionalisation approaches available, allowing for the attachment of many different therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

2023

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Carbon nanomaterials (CNMs) are an incredibly versatile class of materials that can be used as scaffolds to construct anticancer nanocarrier systems. The ease of chemical functionalisation, biocompatibility, and intrinsic therapeutic capabilities of many of these nanoparticles can be leveraged to design effective anticancer systems. This article is the first comprehensive review of CNM-based nanocarrier systems that incorporate approved chemotherapy drugs, and many different types of CNMs and chemotherapy agents are discussed. Almost 200 examples of these nanocarrier systems have been analysed and compiled into a database. The entries are organised by anticancer drug type, and the composition, drug loading/release metrics, and experimental results from these systems have been compiled. Our analysis reveals graphene, and particularly graphene oxide (GO), as the most frequently employed CNM, with carbon nanotubes and carbon dots following in popularity. Moreover, the database encompasses various chemotherapeutic agents, with antimicrotubule agents being the most common payload due to their compatibility with CNM surfaces. The benefits of the identified systems are discussed, and the factors affecting their efficacy are detailed.

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Section: Discussionmentioning

confidence: 99%

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

2023

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“…So, combination therapy results in high efficiency and reduction of dosage of drugs, which in turn can effectively decrease the potential side effects of the administration of free drugs. 90…”

Section: Combinatorial Approaches For Dox Deliverymentioning

confidence: 99%

Carbon nanomaterials as carriers for the anti-cancer drug doxorubicin: a review on theoretical and experimental studies

Gayathri,

Vidya

2024

Nanoscale Adv.

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“…They triggered apoptosis and cell cycle arrest and provided a synergistic impact between DOX and CP. 64 Therefore, carbon-based nanomaterials are ideal candidates. 65,66 Liposome-mediated drug delivery has been of importance.…”

Section: Synthetic Moleculesmentioning

confidence: 99%

“…The nanocarriers had 70 nm size, and they showed high cellular uptake. They triggered apoptosis and cell cycle arrest and provided a synergistic impact between DOX and CP 64 . Therefore, carbon‐based nanomaterials are ideal candidates 65,66 …”

Section: Drug Deliverymentioning

confidence: 99%

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Ashrafizadeh

Zarrabi

Bigham

et al. 2023

Medicinal Research Reviews

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Breast cancer is the most malignant tumor in women, and there is no absolute cure for it. Although treatment modalities including surgery, chemotherapy, and radiotherapy are utilized for breast cancer, it is still a life‐threatening disease for humans. Nanomedicine has provided a new opportunity in breast cancer treatment, which is the focus of the current study. The nanocarriers deliver chemotherapeutic agents and natural products, both of which increase cytotoxicity against breast tumor cells and prevent the development of drug resistance. The efficacy of gene therapy is boosted by nanoparticles and the delivery of CRISPR/Cas9, Noncoding RNAs, and RNAi, promoting their potential for gene expression regulation. The drug and gene codelivery by nanoparticles can exert a synergistic impact on breast tumors and enhance cellular uptake via endocytosis. Nanostructures are able to induce photothermal and photodynamic therapy for breast tumor ablation via cell death induction. The nanoparticles can provide tumor microenvironment remodeling and repolarization of macrophages for antitumor immunity. The stimuli‐responsive nanocarriers, including pH‐, redox‐, and light‐sensitive, can mediate targeted suppression of breast tumors. Besides, nanoparticles can provide a diagnosis of breast cancer and detect biomarkers. Various kinds of nanoparticles have been employed for breast cancer therapy, including carbon‐, lipid‐, polymeric‐ and metal‐based nanostructures, which are different in terms of biocompatibility and delivery efficiency.

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Co-delivery of cisplatin and doxorubicin by carboxylic acid functionalized poly (hydroxyethyl methacrylate)/reduced graphene nanocomposite for combination chemotherapy of breast cancer cells

Cited by 9 publications

References 45 publications

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

Carbon Nanomaterials (CNMs) in Cancer Therapy: A Database of CNM-Based Nanocarrier Systems

Carbon nanomaterials as carriers for the anti-cancer drug doxorubicin: a review on theoretical and experimental studies

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

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