Co-delivery of curcumin and quercetin in the bilayer structure based on complex coacervation

Co-encapsulation of Quercetin and α-Tocopherol Bioactives in Zein Nanoparticles: Synergistic Interactions, Stability, and Controlled Release

“…This finding highlights the considerable influence of α-tocopherol and quercetin on the structural properties of the nanoparticles. This observation is in line with prior studies, such as that by Ma et al, where the co-delivery of curcumin and quercetin with zein nanoparticles led to complex morphological changes as the concentrations of the bioactive compounds increased …”

“…The spectra demonstrate a broad absorption band from 3408 to 3280 cm −1 , which corresponds to O−H stretching vibrations, suggesting the presence of hydrogen bonding, which contributes to the stability of the nanoparticles. 10,11,15 The incorporation of αtocopherol and quercetin into Zein/Que/Toc nanoparticle frameworks was confirmed through the identification of distinct C−H stretching peaks in the range of 2920−2850 cm −1 , which indicates the successful incorporation of the bioactive molecules. 39 These peaks were more pronounced than those observed for pure zein nanoparticles.…”

“…This observation is in line with prior studies, such as that by Ma et al, where the co-delivery of curcumin and quercetin with zein nanoparticles led to complex morphological changes as the concentrations of the bioactive compounds increased. 11 Additionally, the TEM images in Figure 3e−h reveal the morphology of the zein nanoparticles that contain both quercetin and α-tocopherol. The particles were spherical in shape and exhibited an elevated level of stability against aggregation.…”

“…In this study, an antisolvent co-precipitation (ASCP) method was employed to fabricate zein nanoparticles loaded with quercetin and α-tocopherol. Deionized water was utilized as the antisolvent, as previously described by Ma et al 11 The purpose of this approach was to create a stable nanoparticle formulation for codelivery applications. For each formulation, 0.4 g of zein was dissolved in 40 mL of 80:20 ethanol aqueous solution to achieve a concentration of 1% (w/v).…”

“…22,23 The antisolvent precipitation method uses a solution of zein and a solvent that is subsequently introduced into an antisolvent, resulting in the spontaneous self-assembly of zein molecules into nanoparticles or microparticles. 23 This method has been employed to generate zein nanoparticles encapsulating diverse bioactive compounds, such as βcarotene, 24 curcumin, 12 quercetin, 11 and α-tocopherol. 10 The incorporation of bioactive compounds into zein nanoparticles has been demonstrated to increase their stability with respect to light, pH fluctuations, and heating, as well as to enhance their oral bioavailability.…”