Co-delivery of doxorubicin and quercetin via mPEG–PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity

Qureshi, Waseem Akhtar; Zhao, Ruifang; Wang, Hai; Ji, Tianjiao; Ding, Yanping; Ihsan, Ayesha; Mujeeb, Ayeesha; Nie, Guangjun; Zhao, Yuliang

doi:10.1007/s11434-016-1182-z

Cited by 33 publications

(18 citation statements)

References 39 publications

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“…Research data showed that flavonoids combined with anti-cancer drugs produced synergistic as well as attenuated effects ( Yang et al, 2015 ). For example, combination of doxorubicin and quercetin copolymer has synergistic antitumor effect and reduces cardiotoxicity ( Qureshi et al, 2016 ). SCU, commonly used for the treatment of cerebrovascular diseases, is a flavonoid extracted from Erigeron breviscapus (Vant.)…”

Section: Discussionmentioning

confidence: 99%

Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice

et al. 2018

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Bleomycin (BLM) is a broad spectrum anti-tumor drug and inducing pulmonary fibrosis. As an anti-tumor drug without immunosuppression, it is urgent to find a drug that reduces the side effects of BLM. Scutellarin (SCU), a flavone extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has anti-inflammatory activity and ability to inhibit tumor cell growth, migration, and invasion. However, the combined role of SCU and BLM treatment in tumor is unclear. This study aimed to investigate the possible effect and related mechanisms of BLM combined with SCU in the treatment of tumor through in vivo and in vitro experiments. In vivo experiments showed that BLM combined with SCU in the treatment of mice bearing H22 ascites tumor prolonged the survival time, alleviated BLM-induced pulmonary fibrosis, reduced the production of TNF-α; IL-6, and the levels of MDA and MPO. BLM combined with SCU increased the apoptotic rate of H22 ascites cells and the levels of cleaved-caspases-3 and -8. Furthermore, BLM combined with SCU increased the protein expression of p53 and gene expression of miR-29b, and decreased the expression of TGF-β1. In vitro experiment results showed that BLM combined with SCU inhibited the viability of H22 cells and MRC-5 cells, promoted H22 cell apoptosis, up-regulated the protein expression of p53 and down-regulated the protein expression of α-SMA and collagen-I in MRC-5 cells. These experimental results suggested that SCU could enhance the anti-tumor effect of BLM and reduce BLM-induced pulmonary fibrosis, indicating SCU as a potential adjuvant for BLM in the future.

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Section: Discussionmentioning

confidence: 99%

Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice

et al. 2018

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“…The compound is said to kill cancer cells while maintaining serum cardiac levels and cardiac function as well as repairing the damages in cardiac tissues. 41 Better ventricular ejection fraction and normal creatine kinase was exhibited among mice treated with a combination of quercetin and resveratrol micelles. Additionally, doxorubicin dosing can be reduced through chemosensitization as it improved the effectiveness of treatment while protecting the damaging effect on the cardiovascular system.…”

Section: Quercetinmentioning

confidence: 96%

Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review

Othman¹,

Lum²,

Gan³

et al. 2020

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To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed. The categories of keywords used for searching are "Natural Products" or "Phytoconstituents" or "Isolated Compounds" or "Natural Compounds" or "Curcumin" or "Mangiferin" or "Naringenin" or "Quercetin" or "6-Gingerol" or "Lycopene" or "Resveratrol" or "Apigenin" or "Proanthocyanidins" or "Indole-3carbinol" and "Cardioprotection" or "Anticancer" or "Chemotherapy" or "Cardiotoxicity" or "Cardiotonic". After screening of literatures from 2005 to 2019, a total of ten natural products investigated the protective effect against chemotherapy-induced cardiotoxicity and that were included in the present review.

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“…Polymeric nanomaterial‐based drug delivery systems, due to their flexibility and biodegradability, have shown great potential in biomedical applications including drug delivery, diagnosis, therapeutic, and tissue engineering . Many studies have demonstrated that polymeric nanomaterials like polymeric micelles, nanocapsules, nanogels, dendrimers, and polymeric hybrid NPs could be used as nanocarriers to deliver water‐insoluble anticancer drugs, peptides, proteins, DNA, and RNA to the desired site of action (Figure b).…”

Section: Recent Discoveries In Nanotoxicology and Nanomedical Implicamentioning

confidence: 99%

A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805391.The marriage of nanotechnology and medicine offers new opportunities to fight against human diseases. Benefiting from their unique optical, thermal, magnetic, or redox properties, a wide range of nanomaterials have shown potential in applications such as diagnosis, drug delivery, or tissue repair and regeneration. Despite the considerable success achieved over the past decades, the newly emerging nanomedicines still suffer from an incomplete understanding of their safety risks, and of the relationships between their physicochemical characteristics and safety profiles. Herein, the most important categories of nanomaterials with clinical potential and their toxicological mechanisms are summarized, and then, based on this available information, an overview of the principles in developing safe-by-design nanomaterials for medical applications and of the recent progress in this field is provided. These principles may serve as a starting point to guide the development of more effective safe-by-design strategies and to help identify the major knowledge and skill gaps.

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Co-delivery of doxorubicin and quercetin via mPEG–PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity

Cited by 33 publications

References 39 publications

Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice

Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice

Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review

A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines

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