Co-delivery of EGCG and lycopene <i>via</i> a pickering double emulsion induced synergistic hypolipidemic effect

Qun, Wang; Wang, Ling; Khan, Mir Azam; Tian, Wenni; Song, Mingyue; Cao, Yong; Xiao, Jie

doi:10.1039/d2fo00169a

Cited by 13 publications

(3 citation statements)

References 47 publications

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“…Similarly, Sugiura et al reported that combined treatment with EGCG and caffeine (2:1) had overall stronger inhibitory effects on fat accumulation in mice than either alone [ 96 ]. In addition, a recent study reported that the combination of hydrophilic EGCG and lipophilic lycopene synergistically reduced TG and TC levels in serum and liver [ 77 ].…”

Section: Synergistic Hypolipidemic Effects Between Different Categori...mentioning

confidence: 99%

“…It has also been reported that the combination of catechins and caffeine can inhibit fat accumulation by suppressing fatty acid synthesis and up-regulating enzymatic activities involved in β-oxidation of fatty acid in the liver, but the combination of EGCG and caffeine did not show the same effect [ 96 ]. In addition, Wang et al demonstrated that the combination of EGCG and lycopene could synergistically lower lipids through different pathways, including HMGCR, LDLR, PPAR, and AMPK at both mRNA and protein levels, and the synergistic hypolipidemic effects could be achieved mainly through the activation of the AMPK pathway [ 77 ].…”

Section: The Synergistic Hypolipidemic Mechanismsmentioning

confidence: 99%

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Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

Liu

Kou

et al. 2022

Foods

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Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications.

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Section: Synergistic Hypolipidemic Effects Between Different Categori...mentioning

confidence: 99%

Section: The Synergistic Hypolipidemic Mechanismsmentioning

confidence: 99%

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

Liu

Kou

et al. 2022

Foods

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“…This makes DEs a promising co-delivery system for the controlled release of both hydrophilic and hydrophobic bioactive compounds. Over the past few years, numerous hydrophilic and lipophilic bioactive compounds have been simultaneously encapsulated in DEs, including catechin/curcumin [3], EGCG/lycopene [4], EGCG/quercetin [2], vi-tamin C/xanthoxylin [5], phycocyanin/astaxanthin [6], vitamin B12/Cydia pomonella granulovirus (CpGV) [7], and rivoflavin/β-carotene [8].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Gastrointestinal Release of Chlorogenic Acid and Curcumin Co-Encapsulated in Double Emulsions with the Outer Interface Stabilized by Cellulose Nanocrystals

Paredes-Toledo,

Herrera,

Díaz-Calderón

et al. 2024

Colloids and Interfaces

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A Pickering double emulsion (DE) with an outer (O:W2) interface stabilized by cellulose nanocrystals (DE-CNC) was designed as a co-delivery systems for chlorogenic acid (CA) and curcumin, then compared with a control DE emulsion with an O:W2 interface stabilized with sodium caseinate (DE-NaCas). DE-CNC was more resistant to creaming during storage (6.79%, day 42) and showed higher encapsulation efficiency (EE) of CA (>90%). Conversely, both DEs exhibited similarly high EE for curcumin (>97%). The ζ-potential values were highly negative in both DEs, but tended to be lower in DE-CNC due to the highly negative charge of the CNCs. DE-CNC allowed for a steady release of CA during the oral, gastric, and intestinal phases of digestion, while a total release of CA was already observed in the gastric phase in case of DE-NaCas. The bioaccessibility of CA was similar in both DEs (~57–58%). Curcumin was mainly released in the intestinal phase with both DEs, reaching slightly lower bioaccessibility values with DE-CNC. The use of CNCs as a stabilizer for the outer interface of DEs is a promising strategy to increase the stability and EE of these systems, providing oral co-delivery vehicles capable of releasing significantly bioactive compounds during the intestinal phase of digestion.

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Formation of double emulsion droplets in flow-focusing microchips: a numerical parametric study

Hu,

Jiang,

Yan

2024

J Flow Chem

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Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect

Abstract: The concept of “synergy” and its applications has rapidly increased in the food industry as a practical strategy to preserve and improve health-promoting effects of the functional ingredients. In this...

Cited by 13 publications

References 47 publications

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review

In Vitro Gastrointestinal Release of Chlorogenic Acid and Curcumin Co-Encapsulated in Double Emulsions with the Outer Interface Stabilized by Cellulose Nanocrystals

Formation of double emulsion droplets in flow-focusing microchips: a numerical parametric study

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