Co-delivery of gefitinib and hematoporphyrin by aptamer-modified fluorinated dendrimer for hypoxia alleviation and enhanced synergistic chemo-photodynamic therapy of NSCLC

Zhu, Fangyin; Xu, Liang; Li, Xudong; Li, Ziying; Wang, Jun; Chen, Haijun; Li, Xiumei; Gao, Yu

doi:10.1016/j.ejps.2021.106004

Cited by 21 publications

(15 citation statements)

References 54 publications

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Section: Anti Egfr Aptamersmentioning

confidence: 99%

“…An anti-EGFR DNA aptamer was conjugated to a fluorinated dendrimer (APF, Table 15) [239]. Due to the targeting ability of the aptamer and the strong oxygen-carrying capacity of the fluorinated dendrimer, APF could precisely bind to EGFR-positive cells and efficiently alleviate the tumor's hypoxic microenvironment [239]. The dendrimer was used also as a drug carrier to encapsulate photosensitizers, i.e., hematoporphyrin (Hp), as well as drug molecules, i.e., gefitinib (Gef) [239].…”

Section: Anti Egfr Aptamersmentioning

confidence: 99%

“…Due to the targeting ability of the aptamer and the strong oxygen-carrying capacity of the fluorinated dendrimer, APF could precisely bind to EGFR-positive cells and efficiently alleviate the tumor's hypoxic microenvironment [239]. The dendrimer was used also as a drug carrier to encapsulate photosensitizers, i.e., hematoporphyrin (Hp), as well as drug molecules, i.e., gefitinib (Gef) [239]. Under laser irradiation, a significant increase in ROS production was observed intracellularly in EGFR-overexpressing cells.…”

Section: Anti Egfr Aptamersmentioning

confidence: 99%

“…Under laser irradiation, a significant increase in ROS production was observed intracellularly in EGFR-overexpressing cells. The synergistic anticancer effect was promoted by the concurrent application of PDT with the chemotherapeutic action of the gefitinib [239].…”

Section: Anti Egfr Aptamersmentioning

confidence: 99%

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EGFR-Targeted Photodynamic Therapy

et al. 2022

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The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are hallmarks of many human malignancies. As such, EGFR-targeted therapies hold significant potential for the cure of cancers. In recent years, photodynamic therapy (PDT) has gained increased interest as a non-invasive cancer treatment. In PDT, a photosensitizer is excited by light to produce reactive oxygen species, resulting in local cytotoxicity. One of the critical aspects of PDT is to selectively transport enough photosensitizers to the tumors environment. Accordingly, an increasing number of strategies have been devised to foster EGFR-targeted PDT. Herein, we review the recent nanobiotechnological advancements that combine the promise of PDT with EGFR-targeted molecular cancer therapy. We recapitulate the chemistry of the sensitizers and their modes of action in PDT, and summarize the advantages and pitfalls of different targeting moieties, highlighting future perspectives for EGFR-targeted photodynamic treatment of cancer.

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Section: Anti Egfr Aptamersmentioning

confidence: 99%

Section: Anti Egfr Aptamersmentioning

confidence: 99%

Section: Anti Egfr Aptamersmentioning

confidence: 99%

Section: Anti Egfr Aptamersmentioning

confidence: 99%

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EGFR-Targeted Photodynamic Therapy

et al. 2022

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“…Cu-based Fenton reagents have superior ROS yields to Fe-based systems ( Zhu F. et al, 2021 ). In addition, Cu-doped layered double hydroxide (Cu-LDH) nanosheets can not only further enhance the yield of ROS, but also take advantage of the small size and positive charge to actively infiltrate cancer cells for deep tumor therapy ( Wu et al, 2021 ).…”

Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.

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