The current state of the art in mid-infrared fiber lasers is reviewed in this chapter. The relevant fiber-host materials such as silicates, fluorides, chalcogenides, and ceramics, the fiber, pump, and resonator geometries, and the spectroscopic properties of rare-earth ions are introduced. Lasers at transitions ranging from 1.9 to 4 µm occurring in the rare-earth ions Tm 3+ , Ho 3+ , and Er 3+ and their population mechanisms are discussed on the basis of the fundamental spectroscopic properties of these ions. Continuous-wave, fundamental-mode power levels ranging from a few mW near 4 µm up to ≈ 10 W near 2 µm have been demonstrated in recent years. Power-scaling methods and their limitations, the possibilities to optimize the population mechanisms and increase the efficiencies of these lasers, as well as the prospects of future mid-infrared fiber lasers in a number of rare-earth ions at transitions in the wavelength range beyond 3 µm and extending to 5 µm are described.