Co-encapsulation of curcumin and tamoxifen in lipid-chitosan hybrid nanoparticles for cancer therapy

Alhajamee, Maitham; Marai, Khadeeja; Abbas, Sameer Mohammed Naser Al; Tabrizi, Masoud Homayouni

doi:10.1080/10667857.2021.1926811

Cited by 35 publications

(11 citation statements)

References 54 publications

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“…New approaches have been reported—e.g., the use of erythrocytes as ”capsules” for drugs [ 23 ]. In the last decade, encapsulation of drugs for anti-cancer therapies [ 24 ] as well as nanoparticles [ 25 , 26 ] have attracted significant interest.…”

Section: Encapsulated Agentsmentioning

confidence: 99%

“…Generally, all encapsulated compounds are supposed to be safely transported to the site of action (for both oral and non-oral methods of administration). Therefore, encapsulation may protect sensitive compounds (e.g., different types of drugs, various substances for functional foods and food supplements, such as polyphenols or probiotics) as well as the surrounding organs, tissues and cells against aggressive substances (e.g., cancer therapies) [ 24 , 45 , 93 ].…”

Section: Behaviour and Distributions Of Dispersions In The Human Bodymentioning

confidence: 99%

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Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

et al. 2023

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There is a growing demand for efficient medical therapies without undesired side effects that limit their application. Targeted therapies such as deliveries of pharmacologically active compounds to a specific site of action in the human body are still a big challenge. Encapsulation is an effective tool for targeted deliveries of drugs and sensitive compounds. It has been exploited as a technique that can manage the required distribution, action and metabolism of encapsulated agents. Food supplements or functional foods containing encapsulated probiotics, vitamins, minerals or extracts are often part of therapies and currently also a consumption trend. For effective encapsulation, optimal manufacturing has to be ensured. Thus, there is a trend to develop new (or modify existing) encapsulation methods. The most-used encapsulation approaches are based on barriers made from (bio)polymers, liposomes, multiple emulsions, etc. In this paper, recent advances in the use of encapsulation in the fields of medicine, food supplements and functional foods are highlighted, with emphasis on its benefits within targeted and supportive treatments. We have focused on a comprehensive overview of encapsulation options in the field of medicine and functional preparations that complement them with their positive effects on human health.

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Section: Encapsulated Agentsmentioning

confidence: 99%

Section: Behaviour and Distributions Of Dispersions In The Human Bodymentioning

confidence: 99%

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

et al. 2023

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“…Different hybrid nanoparticles were proposed for co-encapsulation; TMX and curcumin [ 87 ]. TMX was entrapped into chitosan, curcumin into lipid, and the resulting mixture formed lipid–chitosan NPs.…”

Section: Cs Np Platforms For a Specific Drug Deliverymentioning

confidence: 99%

“…Several reports also describe more sophisticated systems for curcumin delivery or those dedicated to the co-delivery of several anticancer agents [ 43 , 72 , 87 ]. Magnetic iron(II, III) oxide nanoparticles were coated with CUR-loaded carboxymethyl CS and combined with hyperthermia as a proposed strategy for breast cancer treatment [ 95 ].…”

Section: Cs Np Platforms For a Specific Drug Deliverymentioning

confidence: 99%

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Kurczewska

2023

Pharmaceutics

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Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery systems of different active agents. Recently, much attention has been paid to nanodelivery systems as carriers to enable better bioavailability, and thus higher efficiency of the loaded drug. The present review is focused on the progress in chitosan-based nanoparticles for the targeted delivery of antitumor drugs. The paper discusses literature reports from the last three years in which chitosan nanoparticles were applied as carriers for active substances used in antitumor therapy and potential new drugs with anticancer properties. Special attention was paid to the different treatments applied to increase the therapeutic effectiveness and minimize the side effects of a specific active substance.

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“…The intrinsic antitumor and antimicrobial properties of chitosan have attracted interest in enhancing the efficacy of corresponding loaded substances [23,30]. To put the antitumor potential of this material to use, particular attention has been drawn to the delivery of a plethora of anti-cancer drugs [28] such as doxorubicin [31,32], paclitaxel [33][34][35][36], docetaxel [33,37,38], tamoxifen [39,40], curcumin [40][41][42][43], cisplatin [44,45], and mitomycin C [46,47]. The resulting nanosystems are able to reduce side toxicity while increasing treatment efficiency [28].…”

Section: Natural Polymers 211 Chitosanmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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Co-encapsulation of curcumin and tamoxifen in lipid-chitosan hybrid nanoparticles for cancer therapy

Cited by 35 publications

References 54 publications

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific Anticancer Drug—A Comprehensive Review

Polymer-Based Nanosystems—A Versatile Delivery Approach

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