2016
DOI: 10.1016/j.msec.2015.12.053
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Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid–polymer hybrid nanoparticles: In vitro and in silico studies

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Cited by 69 publications
(52 citation statements)
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“…The high binding energy can cause a slow release of the encapsulated drugs. 25 In contrast, the dissolution rates of the unprocessed Dexi and marketed tablets were observed to be very low at 0.6% and 2.5%, respectively. A 117-and 108-fold increase in dissolution rates of the Dexi nanocrystals HPMC-EUD-Dexi and HPMC-PVP-Dexi, respectively, compared to the unprocessed Dexi, was observed.…”
Section: Dissolution Studies Of Deximentioning
confidence: 95%
See 1 more Smart Citation
“…The high binding energy can cause a slow release of the encapsulated drugs. 25 In contrast, the dissolution rates of the unprocessed Dexi and marketed tablets were observed to be very low at 0.6% and 2.5%, respectively. A 117-and 108-fold increase in dissolution rates of the Dexi nanocrystals HPMC-EUD-Dexi and HPMC-PVP-Dexi, respectively, compared to the unprocessed Dexi, was observed.…”
Section: Dissolution Studies Of Deximentioning
confidence: 95%
“…From previous experience, molecular modeling studies ( Figure 2) are helpful in providing mechanistic insight at the molecular level, which could not be ascertained from traditional experiments. 24,25 International Journal of Nanomedicine 2018:13 submit your manuscript | www.dovepress.com…”
Section: Introductionmentioning
confidence: 99%
“…Seedat, N. et al [85] used eudragit RS100 (EUD) as polymer, and four different lipids glyceryl tripalmitate (GTP), OA, CT, and sodium alginate (ALG), to entrap vancomycin (VCM). The encapsulation efficiencies of the nanoparticles were 27.8%, 41.5%, 54.3%, and 69.3%, respectively.…”
Section: Methods For Preparing Drug Carriersmentioning
confidence: 99%
“…FA-NC-F12 and FA-NC-F12/L creams showed more effective antibacterial activity compared to Fucidin cream as indicated by their significantly larger inhibition zones (p < 0.05). It is acknowledged that the smaller the PS is, the greater the extent of uptake through a barrier membrane e.g., bacterial cell wall which is usually followed by higher cellular uptake [63]. The antibacterial activity of FA-NC-F12/L and FA-NC-F12 creams against both S. aureus and S. epidermidis was not statistically significantly different (p > 0.05).…”
Section: Microbiological Studiesmentioning
confidence: 99%